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代谢组学在预测胚胎发育潜能中的研究进展 被引量:1

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摘要 体外授精-胚胎移植技术发展20多年来,促排卵及胚胎培养技术有了很大进步,但是活婴出生率通常低于50%。而多个胚胎移植提高了多胎等相关风险,因此业界提倡单胚胎或单囊胚移植。准确评估胚胎的活力对实现该目标至关重要。目前除了胚胎形态学评级,对胚胎代谢的相关研究也反应了胚胎的活力。本文综述了国内外近年来对胚胎代谢的相关研究,为更好选择高活力胚胎,降低多胎率,减少多胎带来的母婴风险提供新的思路。
作者 宋蕊 王树玉
出处 《中国优生与遗传杂志》 2016年第10期7-9,共3页 Chinese Journal of Birth Health & Heredity
基金 首都医科大学附属北京妇产医院北京妇幼保健院中青年学科骨干培养专项(FCYY201507)
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  • 1Pharoah PO, Cook T. Cerebral palsy and multiple births[J]. Arch Dis Child Fetal Neonatal Ed, 1996, 75 :F174-F177.
  • 2Basak B, Daniel B, Gloria C, et al. The Istanbul consensus work- shop on embryo assessment :proceedings of an exper meeting[J]. Hum Reprod, 2011, 26 (6) :1270-1283.
  • 3Market-Velker BA, Fernandes AD, Mann MR. Side-by-side comparison of five commercial media systems in a mouse model : suboptimal in vitro culture interferes with imprint maintenance [J]. Biol Reprod, 2010,83:938-950.
  • 4Nicholson JK, Lindon JC, Holmes E, et al. ' Metabonomics ' understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J]. Xenobiotica, 1999,29 : 1181-1189.
  • 5Gardner DK, Wale PL. Analysis of metabolism to select viable human embryos for transfer[J]. Fertil Steril, 2013,99 (4) 1062-72.
  • 6Conaghan J, Hardy K, Handyside AH, et al. Selection criteria for human embryo transfer :a comparison of pyruvate uptake and morphology [J].J Assist Reprod Genet, 1993,10:21-30.
  • 7Seli E, Botros L, Sakkas D, et al. Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization[J]. Fertil Steril, 2008,90(6) 2183-9.
  • 8Gardner DK, Leese HJ. Assessment of embryo viability prior to transfer by the noninvasive measurement of glucose uptake[J].J Exp Zool, 1987,242:103-5.
  • 9Gardner DK, Wale PL, Collins R, Lane M. Glucose consumption ofsingle post-compaction human embryos is predictive of embryo sex and live birth outcome[J].Hum Reprod, 2011,26:1981-6.
  • 10Leese HJ. Metabolism of the preimplantation embryo :40 years on[J]. Reproduction, 2012,143 (4) :417-27.

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