摘要
MS是一组以肥胖、高血糖、血脂异常及高血压等为主要特征的症候群,发病机制以IR为核心。代谢性疾病与长期能量正平衡导致的肥胖有关。肥胖实质是一种低度炎症反应,先天免疫反应参与此过程。其中,Toll样受体4(TLR4)可能是肥胖致低度炎症反应的一个关键调节点。本文将阐述TLR4介导的炎症反应与肥胖和1R之间的关系。
The metabolic syndrome (MS)is a group of symptoms characterized by obesity, hyperglycemia,dyslipidemia and hypertension. Insulin resistance was the core of the pathogenes. The metabolic disease is related to the long-term positive energy balance and obesity. The essence of obesity is a low degree of inflammation reaction, in which innate immune response is involved. In this process, Toll like receptor 4(TLR4) may be a key regulatory point. Here, we reviewed the relationship between TLR4 mediated inflammation and obesity and insulin resistance.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2016年第11期1044-1048,共5页
Chinese Journal of Diabetes
基金
苏州市社会发展项目(SYS 201603)
关键词
TOLL样受体4
糖尿病
2型
慢性低度炎症
胰岛素抵抗
肥胖
Toll like receptor 4(TLR4)
Diabetes mellitus, type 2
Chronic low-grade inflammation
Insulin resistance(IR)
Obesity