经皮穿刺微波凝固联合替吉奥治疗胃癌肝转移的疗效观察

Efficacy of Percutaneous Microwave Coagulation Therapy Combined with Gio Liver Metastasis of Gastric Cancer

目的探索经皮穿刺微波凝固(PMCT)联合替吉奥治疗胃癌肝转移的临床疗效。方法胃癌根治术后肝转移的患者60例,进行随机均分成对照组和观察组,观察组30例采用经皮穿刺微波凝固联合替吉奥治疗进行治疗;对照组30例单独采用经皮穿刺微波凝固进行治疗。观察比较两组的有效率及不良反应。结果治疗后观察组完全缓解17例,部分缓解8例,稳定2例,进展3例,总缓解率为83.3%,对照组完全缓解10例,部分缓解8例,稳定6例,进展6例,总缓解率为60.0%,两组相比均有统计学差异(P<0.05)。两组患者的不良反应主要为贫血、恶心、发热、腹痛、肝功能轻度异常,比较无差异无统计学意义(P>0.05)。结论对胃癌转肝癌的患者进行经皮穿刺微波凝固联合替吉奥治疗,效果显著,不良反应较轻,为治疗胃癌肝转移提供了良好的前景,值得临床推广。

Objective To explore the percutaneous microwave coagulation（ PMCT） combined with Gio clinical efficacy of liver metastasis of gastric cancer treatment. Methods 60 patients with gastric cancer patients with liver metastasis,and were randomly divided into a control group and observation group,observation group of 30 cases with percutaneous microwave coagulation therapy combined with Gio treatment; 30 cases in the control group alone percutaneous microwave coagulation treatment. Two groups were observed effectiveness and adverse reactions. Results After treatment,complete remission was observed in 17 cases,eight cases of partial remission,stable in 2 cases,3 cases of progress,the overall response rate was 83. 3% in the control group,10 cases of complete remission,partial remission in 8cases,6 cases of steady progress in 6 cases,The overall response rate was 60. 0%,compared to the two groups were statistically significant（ P〈0. 05）. Adverse reactions are mainly two groups of patients anemia,nausea,fever,abdominal pain,mild abnormal liver function,no difference was not statistically significant（ P〉0. 05）. Conclusions The patients with gastric cancer were transfected liver cancer percutaneous microwave coagulation therapy combined with Gio,the effect is significant,mild adverse reactions,for the treatment of liver metastasis of gastric cancer provides a good prospect.