川芎嗪注射液联合常规疗法对大面积脑栓塞患者支架植入术后血小板血流变学及疗效的影响

Effect of Ligustrazine Injection Combined with Conventional Therapy on Platelet,Blood Rheology and Efficacy in the Patients with Large Area Cerebral Embolism

目的：探讨川芎嗪注射液联合常规疗法对大面积脑栓塞患者术后血小板及血流变学的影响。方法：2014年1月~2015年1月,100例大面积脑栓塞患者随机分为对照组和观察组各50例。对照组患者术后采用常规治疗,观察组患者在对照组基础上加用川芎嗪注射液。两组疗程均为2周。比较两组患者治疗前、治疗后1周、治疗后2周的神经功能损失（NIHSS评分）、血小板聚集率及血液流变学（全血黏度、血浆黏度、红细胞变形指数、红细胞聚集指数、纤维蛋白原）指标变化,评价两组疗效与药品不良反应。结果：治疗后,观察组与对照组的有效率分别为92.00%与80.00%,差异无统计学意义（P〉0.05）。治疗后1周、2周,两组NIHSS评分、血小板聚集率、血液流变学各项指标均较治疗前显著改善（P〈0.05）;且观察组改善较对照组更为明显（P〈0.05）。观察组药品不良反应发生率明显低于对照组（P〈0.05）。结论：在常规治疗基础上加用川芎嗪注射液,可抗血小板聚集,改善血液流变学指标,在治疗大面积脑栓塞的疗效确切。

Objective： To explore the effect of ligustrazine injection combined witll the conventional therapy on platelet and blood theology in the patients with large area cerebral embolism. Methods： From January 2014 to January 2015, 100 cases of large area cerebral embolism patients were divided into the treatment group and the control group with the treatment course of 2 weeks. The patients in the control group were treated with the routine treatment, and those in the treatment group were treated with the conventional treatment combined with lignstrazine. The curative effect, loss of neurological function score, platelet aggregation rate and changes of blood rheo-logical indices （blood viscosity, plasma viscosity, erythrecyte deformation index and erythrocyte aggregation index, fibrinogen） in the two groups were compared before the treatment, and 1 week and 2 weeks after the treatment. Results： After the treatment, the effective rate of the control group and the treatment group was 80% and 92%, respectively（ P 〉 0.05 ）. Before the treatment, the loss of neuro- logical function score of the treatment group and the control group had no significant difference （ P 〉 0.05 ）, while 1 week and 2 weeks after the treatment, the loss of neurological function score in the treatment group was significantly lower than that in the control group （P 〈 0.05）. Before the treatment, there was no significant difference in the platelet aggregation rate between the groups （ P 〉 0.05 ）, while that in the treatment group was significantly lower than that in the control group （P 〈 0.05） after 1-week and 2-week treatment. Before the treatment, the blood rheological indices of the treatment group and the control group had no significant differences （P 〉 0. 05 ）, while those in both groups were improved after the treatment, and the improvement in the treatment group was more obvious （ P 〈 0.05 ）. Conclusion： The conventional treatment combined with ligustrazine injection has anti-platelet aggregation effect, which can improve blood theological indices and has exactly curative effect in the patients with large area cerebral embolism.