丁苯酞联用丹参多酚酸注射液对大面积脑梗死患者的疗效及SOD酶的影响

Efficacy of Butylphthalide Combined with Salvianolate Injection in the Patients with Large Area Cerebral Infarction and its Influence on SOD Enzyme

目的:探讨丁苯酞联用丹参多酚酸注射液对大面积脑梗死患者的疗效及SOD酶的影响。方法:120例大面积脑梗死患者随机分为丁苯酞组、丹参多酚酸组和丁苯酞联用丹参多酚酸组,疗程均为2周,比较3组患者治疗后1周及治疗后2周的疗效,以及治疗前后Bathel指数评分、NIHSS评分及血中SOD酶含量的变化,记录3组药品不良反应发生情况。结果:丁苯酞联用丹参多酚酸组的有效率,明显高于丁苯酞组和丹参多酚酸组(P<0.05)。治疗后,3组患者的Bathel指数评分、NIHSS评分和SOD酶含量均较治疗前明显改善(P<0.05),且丁苯酞联用丹参多酚酸组均优于丁苯酞组与丹参多酚酸组(P<0.05)。3组药品不良反应发生率差异无统计学意义(P>0.05)。结论:丁苯酞联合丹参多酚注射液在治疗大面积脑梗死的疗效确切,值得在临床推广运用。

Objective： To explore the curative effect of butylphthalide combined with salvianolate injection in the patients with large area cerebral infarction and its influence on SOD enzyme. Methods： Totally 120 cases of patients with.large area cerebral infarction were divided into three groups with different treatment for 2 weeks. The patients in group A were treated with butylphthalide, those in group B were treated with salvianolic acid injection, and those in group C were treated with styrene butylphthalide and salvianolic acid. The curative effect and the changes of Bathel index, NIHSS score and blood SOD content among the three groups were compared after the 1- and 2-week treatment. Results： For the patients with large area cerebral infarction, the curative effect of the combination of butylphthalide and salvianolate injection was significantly higher than that of butylphthalide group and salvianolate injection group （P 〈 0.05）. After the treatment, Bathel index, NIHSS score and SOD content in the three groups were all improved when compared with those before the treatment （P 〈 0.05 ）, and the improvement in the combination group was more notable than that in two other groups （P 〈 0.05 ）.The incidence of adverse drug reactions among the three groups showed no significant difference （ P 〉 0.05 ）. Conclu- sion： Butylphthalide combined with salvianolate injection in the treatment of patients with large area cerebral infarction is effective, which is worthy of promotion in clinics.