SOD酶模型配合物的合成及催化歧化作用——1,3,4-噻二唑类希夫碱配合物的合成、表征及对超氧离子的抑制作用

The Synthesis and Catalytic Activity of the Model Complexes of SOD in O_2^(·-) Disproportionation --Synthesis and Characterization of Novel Schiff Base Complexes of 1,3,4-Thiadiazole and their Free Radical Inhibition Ratesto O_2^(·-)

合成了 2 -氨基 -5 -巯基 -1 ,3 ,4-噻二唑缩 2 ,4-二羟基苯甲醛及其与 Cu( ) ,Co( ) ,Zn( )的配合物 ,通过元素分析、摩尔电导、IR及其电子光谱对其组成和结构进行了表征。活性实验表明 ,配合物均对超氧离子有一定的抑制效果。

A new Schiff base ligand was synthesized by condensating 2 amino 5 mercapto 1,3,4 thiadiazole and 2,4 dihydroxybenzaldehyde. The compositions and structures of the ligand and its complexes of Cu(Ⅱ), Co(Ⅱ) or Zn(Ⅱ) have been characterized by elemental analysis, molar conductivity, IR spectrum and electronic absorption spectrum. Their free radical inhibition rates to O ·- 2 have also been tested. The results showed that all of the complexes displayed significant activities and the copper(Ⅱ) complexe showed the best inhibitive effect.