α'-取代磺酰基-α,β-不饱和酮的不对称催化环加成反应的研究

Asymmetric Diels-Alder Reactions of (E)-1-Substituted Sulfonyl-3-penten-2-ones with Cyclopentadine Catalyzed by a Chiral Titanium Reagent

在手性金属钛配合物催化剂存在下 ,研究了 α -取代磺酰基 -α,β-不饱和酮的不对称催化环加成反应 ;讨论了α,β-不饱和酮各种取代磺酰基对反应活性和对映选择性的影响 ;高收率地合成了高光学纯度的环加成产物 ,并对环加成产物的构型进行了鉴定。

Asymmetric Diels Alder reactions of (E) 1 substituted sulfonyl 3 penten 2 ones with cyclopentadine catalyzed by a chiral titanium reagent were investigated. The enantioselectivity was discussed with different substituents in the position of sulfonyl moiety. 6 Methyl 5 (substituted sulfonylacetyl)bicyclo 2 heptenes(2) were prepared in high yield with high optical purity. The absolute configuration of the cycloadducts was determined by comparing with the authentic samples of 2, which were prepared by an alternative synthetic route.