摘要
近年来,支气管哮喘(哮喘)病死率有所下降,但发病率仍不断攀升,且至今尚无有效治愈的方法。呼吸道病毒感染是哮喘急性发作和加重的首要原因,尤其以鼻病毒(RV)A型和C型感染最为常见。婴儿早期RV感染可增加日后哮喘发生的风险;同时,RV感染所导致的免疫应答异常、激活Ⅱ型固有淋巴样细胞促进Th2细胞介导的炎性反应、抑制调节性T淋巴细胞(Treg细胞)的生成导致Treg/Th2细胞失衡等机制与哮喘急性发作、加重密切相关。针对RV危险血清型的疫苗与抗体研究策略,有望为哮喘提供新的治疗靶点。
Despite falling mortality rates, increasing prevalence of asthma persists and there is still no available therapeutic regimens can cure asthma. Infection with respiratory viruses, especially human rhinovirus (RV) -A and RV - C, is a major risk factor for asthma exacerbations. There is increasing evidence linking RV infection in infants to a subsequent diagnosis of childhood asthma. Meanwhile, RV can induce abnormal immune response, activate the type - 2 innate lymphoid cell leading to the enthanced type 2 inflammation and suppress the normal generation of regulatory T - cell(Treg cell) resulting in the imbalance of Treg/Th2, all of which conspire the acute asthma attacks and exacerbations. To explore and target the more asthmagenic RV subtypes for vaccination and antibodys research will lay the foun- dation for the targeted therapy.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2016年第21期1678-1680,共3页
Chinese Journal of Applied Clinical Pediatrics
关键词
支气管哮喘
鼻病毒
呼吸道感染
靶向治疗
Asthma
Rhinovirus
Respiratory tract infection
Targeted therapy