计算流体力学在脑动脉瘤诊治中的应用

Application of computational fluid dynamics in clinical treatment of cerebral aneurysms

近年来,计算流体力学(computational fluid dynamics,CFD)被广泛应用于脑动脉瘤的基础和临床研究中,其研究方向涉及:1动脉瘤的形成、生长机制和动脉瘤破裂的血流动力学危险因素,2通过建立患者个性化模型,评估弹簧圈和支架置入后动脉瘤内流场的变化,评价血管内治疗的效果。从计算流体力学模型的建立、评估动脉瘤破裂风险的形态和血流动力学参数以及血流动力学参数评估动脉瘤治疗的手术效果3个方面详细阐述近年来在脑动脉瘤的诊治中血流动力学研究的进展。

In recent years, computational fluid dynamics （CFD） has been widely used in fundamental and clinical researches of cerebral aneurysms. The research direction involves： （1） the hemodynamic risk factors associated with initiation, evolution and rupture of cerebral aneurysms, （2） the assessment of flow field changes in cerebral aneurysms after the implantation of coils and stent as well as the effect of such endovascular treatment by estab- lishing the patient-specific models. This review elaborates the research progress in hemodynamics of cerebral an- eurysms from 3 aspects： the development of CFD models, the morphological and hemodynamic parameters for rupture risk assessment of aneurysms and the effect of hemodynamic parameters on assessing the endovascular treatment of cerebral aneurysms.