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IL-22及肠道干细胞在肠黏膜屏障中的作用 被引量：5

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摘要 肠道担负着消化、吸收、内分泌、防御等功能,而隐窝底部肠道干细胞（intestinal stem cells,ISCs）的增殖、分化是肠道肠黏膜更新的主要细胞学基础。当肠道受到外界损伤时,ISCs可以促进肠道结构与功能的修复,对维持肠道屏障结构和功能的完整性具有重要作用。
作者 成海燕 张亚姝 迟宏罡
机构地区 广东医科大学第二临床医学院中医学教研室
出处 《广东医学》 CAS 北大核心 2016年第20期3133-3135,共3页 Guangdong Medical Journal
基金 国家自然科学基金面上项目(编号:81573932) 广东省医学科研基金资助项目(编号:B2014295)
关键词 肠黏膜屏障 IL-22 肠道干细胞 肠隐窝 肠道屏障 肠上皮细胞 类器官 组织再生 炎症性肠病 潘氏细胞
分类号 R574 [医药卫生—消化系统]
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参考文献28

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  • 2Barker N, Vanoudenaarden A, Clevers H. Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls [ J ]. Cell Stem Cell, 2012, 11(4): 452-460.
  • 3Tian H, Biehs B, Warming S, et al. A reserve stem cell popula- tion in small intestine renders Lgr5 -positive ceils dispensable [J]. Nature, 2011,478(7368): 255-259.
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  • 9平晓春,李幼生.肠黏膜更新的源泉——小肠干细胞[J].中华细胞与干细胞杂志（电子版）,2011,1(2):56-62. 被引量：3
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二级参考文献38

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二级引证文献12

广东医学
2016年 第20期

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