三阴性乳腺癌危险因素及临床特征分析

Risk factors and clinical characteristics of triple negative breast cancer

目的探讨三阴性乳腺癌(triple negative breast cancer,TNBC)的相关危险因素及临床病理学特征。方法 210例乳腺癌患者,70例TNBC患者为观察组,140例非TNBC患者为对照组,比较2组一般资料,分析TNBC的危险因素以及临床病理学特征。结果 2组年龄、体质量指数、泌乳情况、使用避孕药以及产次比较差异均有统计学意义(P<0.05);多因素logistic回归分析显示,体质量指数>25kg/m^2(OR=9.604,95%CI:3.670~89.237,P=0.002)、抑制泌乳(OR=9.00,95%CI:1.070~75.668,P=0.043)、使用避孕药(OR=13.280,95%CI:3.322~113.423,P=0.006)是TNBC发生的危险因素;TNBC主要表现为进展期浸润性导管癌,且具有更高的T、M分期。结论肥胖、抑制泌乳以及口服避孕药是女性TNBC发生的危险因素,TNBC恶性程度高于非TNBC。

Objective To explore the risk factors and clinicopathologic characteristics of triple negative breast cancer （TNBC）. Methods In 210 patients with breast cancer, there were 70 patients with TNBC （observation group） and 140 patients with other diseases （control group）. The general data, risk factors and clinicopathological characteristics were analyzed in two groups. Results There were significant differences in the age, body mass index, lactation status, use of contraceptive agents and numbers of childbirth between two groups （P〈0.05）. Multivariable logistic regression analysis showed body mass index 〉25 kg/m^2 （OR = 9. 604, 95% CI： 3. 670 to 89. 237, P = 0. 002）, suppression of lactation （OR：9. 000, 95%CI： 1. 070 to 75. 668, P=0. 043）, and the use of contraceptive agents （OR=13. 280, 95%CI： 3. 322 to 113. 423, P=0. 006） were the risk factors for TNBC. The main type of TNBC was the advanced infiltrating ductal carcinoma, with higher T and M stages. Conclusion Obesity, suppression of lactation and the use of contraceptive agents are the risk factors for TNBC. The malignant degree of TNBC is higher than non-TNBC.