脑外伤颅内感染患者脑脊液检查病原菌分布及耐药性分析

Distribution and drug resistance of pathogenic bacteria in cerebrospinal fluid of patients with intracranial infection

目的探讨脑外伤颅内感染患者脑脊液病原菌分布及其耐药性。方法 80例颅内感染患者,按照感染原因分为外伤组(32例)和非外伤组(48例),分析两组患者脑脊液病原菌特点及外伤组患者细菌种类和耐药性。结果外伤组患者革兰阴性菌感染率明显高于非外伤组,革兰阳性菌感染率明显低于非外伤组(P<0.05)。外伤组患者脑脊液中耐药菌主要是金黄色葡萄球菌和凝固酶阴性葡萄球菌,对于高级抗生素如亚胺培南、万古霉素等均不存在耐药菌。结论脑外伤颅内感染患者脑脊液病原菌多以革兰阴性菌为主,不同病原菌的耐药性存在一定差异。

Objective To analyze the distribution and drug resistance of pathogenic bacteria in cerebrospinal fluid of patients with intracranial infection.Methods 80 patients with intracranial infection were selected in our hospital.According to the difference of infection causes,patients were divided into 32cases and 48 cases respectively.Analyzed the characteristics of pathogenic bacteria in the two groups of patients with cerebrospinal fluid.Results The infection rate of gram negative bacteria in trauma group was significantly higher than that in non trauma group,and the infection rate of gram positive bacteria was lower than that of non traumatic group （ P〈0. 05） .Trauma group in cerebrospinal fluid of patients with resistant bacteria was mainly Staphylococcus aureus and coagulase negative staphylococci,for advanced antibiotics such as imipenem,vancomycin resistant bacteria do not exist.Conclusion The pathogens of ce-rebrospinal fluid in patients with brain injury were mainly Gram-negative bacteria,and there were some differences in the drug resist-ance of different pathogenic bacteria.