儿童过敏性紫癜复发预测因素的研究进展

Research Progress in the Relapse Predictive Factors of Children with Henoch-Schonlein Purpura

过敏性紫癜(HSP)是一种由免疫球蛋白A(IgA)介导的全身性小血管炎,临床特征以非血小板减少性紫癜、关节炎或关节痛、腹痛及肾损害为主。儿童HSP是皮肤科常见疾病之一,大部分患儿病程呈自限性,但易复发。发病年龄晚、感染、食物过敏、剧烈运动、皮疹持续时间长或频繁反复、有消化道并发症、有肾损害、血小板计数增多、单核细胞数增多、血清IgG或IgA升高、D-二聚体升高、IgM-抗磷脂抗体阳性以及IgA-髓过氧化物酶型抗中性粒细胞胞质抗体阳性可能与儿童HSP复发有关,且频繁复发会对患儿的远期预后造成不良影响,临床医师应予以注意。

Henoch-Schordein Purpura （HSP） is an immunoglobin A （IgA）-mediated systemic polyangi- tis, clinically characterized by non-thrombocytopenic purpura, arthritis or arthralgia, abdominal pain and renal damage. It＇s a common disease in dermatology, which is self-limited, but relapse often occurs. The later onset age, infection, food allergy, strenuous exercise, persistent rash or repeated frequently rash, gastrointestinal tract complications, renal damage, increased platelet count, elevated serum levels of IgG or IgA, increased D-dimer, IgM antiphospholipid antibody positive and IgA perinuelear-pattern antineutrophil cytoplasmic anti- body positive may be related to the HSP recurrence. Frequent relapse can affect the long-term prognosis of children with HSP,calling for the due attention of the clinicians.