聚焦超声治疗宫颈上皮内瘤变Ⅰ级病变合并HPV感染的临床效果观察

Study on the Focused Ultrasound in treatment with cervical intraepithelial neoplasia Ⅰcombined with HPV infection

目的探讨聚焦超声治疗宫颈上皮内瘤变Ⅰ(CINⅠ)级合并HPV感染的的临床治疗效果。方法 152例HPV阳性,经阴道镜取活检,病理确诊为宫颈上皮内瘤变Ⅰ级同时经检测合并HPV感染的患者,应用聚焦超声治疗,随访观察疗效及HPV的转阴情况。结果所有患者治疗顺利,未出现创面大出血情况,阴道排液时间约为1-2周,未见脱痂致大量阴道出血,所有患者治疗后六个月门诊随诊:139例患者宫颈恢复为正常生理结构形态,无瘢痕形成,阴道镜检查见成熟鳞状上皮、柱状上皮、转化区上皮,对13例异常阴道镜表现患者取活检行病理检查结果为11例仍为CINⅠ,两例进展为CINⅡ,有效率91.44%;136例患者HPV转阴,HPV的转阴率为89.47%。结论聚焦超声是一种安全、有效的治疗宫颈CINⅠ级合并HPV感染的手段,值得在临床上广泛应用和推广。

Objective To investigate the clinical efficacy of Focused ultrasound for treatment of cervical intraepithelial neoplasia Ⅰcombined with HPV infection.Methods 152 women with cervical intraepithelial neoplasia Ⅰcombined with HPV infection cases were given Focused ultrasound therapy,follow up the treatment effect and the number of HPV negative cases.Results Ultrasound therapy was performed well,no severe complications were observed in any patient.Vaginal discharge was disappeared7-14 days after ultrasound therapy.6 months after therapy,139 with cervical intraepithelial neoplasia were healed,136 patients with HPV negative.Total effectiveness was 91.44%,treatment of HPV overcast rate was 89.47%.Conclusion HIFI is a safe and effective treatment of cervical HPV infection means of CIN1 and be worthy of wide application and popularization in clinic.