重度子痫前期患者凝血功能及vWF含量的变化和意义

The application value of changes in four items of coagulation routine and vWF in severe preeclampsia patients

目的观察重度子痫前期患者凝血四项、血管性假血友病因子(v WF)的变化,探讨其临床检测意义。方法选择2014年1月-2015年12月在我院门诊就诊单胎妊娠无合并症的孕妇30例作为对照组,同期发生子痫前期患者30例作为实验组,用酶联免疫吸附(ELESA)法进行血清v WF水平检测,我院中心实验室进行凝血四项检测。结果实验组PT、APTT低于对照组,Fig、v WF水平高于对照组,有统计学差异。结论重度子痫前期孕妇血液呈高凝状态,v WF水平可作为初步判断其病情严重程度的指标之一。

Objective To observe the application value of prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT） and fibrinogen（FIB）,also with the von Willebrand factor（v WF） on the change characteristics of plasma in severe preeclampsia women and its significance.Methods Detect both 30 case in severe preeclampsia and normal pregnant women in coagulation routine and v WF levels.Results The time of PT and APTT in observation group were lower than those in control group（P〈0.05）.The level of FIB and v WF of severe preeclampsia were higher than those of normal pregnant women（P〈0.05）.Conclusion The blood of pregnant women with severe preeclampsia is in a high coagulation state,and the v WF level can be used as one of the indicators to judge the severity of preeclampsia.