补肾驱邪法对HBeAg阴性慢性乙型肝炎患者生存质量的影响

Effect of Invigorating Kidney and Eliminate Pathogenic Method on Quality of Life in HBeAg-negative Chronic Hepatitis B Patients

目的观察补肾驱邪法对HBe Ag阴性慢性乙型肝炎患者患者临床疗效及生存质量的影响。方法将120例HBe Ag阴性慢性乙型肝炎(CHB)患者随机分为中药治疗组(简称A组)和对照组(简称B组),两组均予以恩替卡韦治疗,同时A组加用补肾驱邪中药颗粒剂口服,共治疗48周。观察两组患者治疗前后血清ALT、AST、HA及HBV DNA水平,并于治疗前后分别进行CLDQ及SF-36量表分值测定。结果 A组患者CLDQ及SF-36量表的各项评分在治疗结束后均有明显提高,差异具有显著性意义(P<0.05),且比单纯使用核苷类药物的患者,各项量表积分也有显著提高(P<0.05)。结论补肾驱邪法在降低病毒复制、改善肝功能基础上,能够明显改善HBe Ag阴性慢性乙型肝炎患者临床症状,提高患者生存质量,延缓疾病进展。

Objective To observe the effect of invigorating kidney and eliminate pathogenic method on quality of life in HBeAg - negative chronic hepatitis B patients. Methods 120 cases of patients with HBeAg - negative CHB were randomly divided into2 groups, the control group was only given entecavir 0.5mg/d, the treatment group was added with invigorating kidney and elimi- nate pathogenic method on the basis of treatment with entecavir. The treatment course was 48 weeks. The relative detection were performed in serum parameters such as ALT, HA and HBV DNA level. Simultaneously, CLDQ and SF - 36 scores were measured before and after treatment. Results CLDQ and SF - 36 scores of patients in group A significantly improved, the different is signifi- cant （ P 〈 O. 05 ） , and the result is higher than that of patients simply given nucleoside analogue. Conclusion Invigorating kidney and eliminate pathogenic method can significantly improve the clinical symptoms of HBeAg - negative chronic hepatitis B, and im- prove the quality of life of patients, delay disease progression besides reduction of viral replication and improvement of liver function. ：