不同药物治疗部分性发作癫痫疗效及对脑电图的影响

Efficacy of different drugs on treatment of partial seizures epilepsy and impacts on EEG

目的探讨左乙拉西坦与奥卡西平治疗成人部分性发作癫痫的临床疗效及对脑电图的影响。方法选择我院治疗的成人部分性发作癫痫患者300例作为研究对象,随机分为A组和B组各150例,分别采用左乙拉西坦或奥卡西平治疗24 w。观察比较两组临床疗效、脑电图变化、不良反应以及患者认知功能。结果治疗后B组总有效率明显优于A组(P<0.05);两组治疗后痫样放电(IEA)变化情况及α、β、δ频段相对功率均无显著差异(P>0.05),B组治疗后θ频段相对功率显著高于治疗前及治疗后A组(P<0.05);两组均未发生严重不良反应;治疗后两组语言智商(VIQ)均显著提高(P<0.05),操作智商(PIQ)、总智商(FIQ)无明显变化(P>0.05)。结论奥卡西平治疗成人部分性发作癫痫疗效优于左乙拉西坦,但对脑电背景活动影响大于左乙拉西坦,临床应结合患者具体情况制定治疗方案。

Objective To explore the efficacy of levetiracetam and oxcarbazepine on the treatment of adult partial epilepsy and the impacts on EEG. Methods A total of 300 patients with adult partial epilepsy admitted to our hospital were selected and randomly divided into groups A and B（n = 150, respectively）. The two groups were treated with levetiracetam and oxcarbazepine respectively for24 weeks. The efficacy and EEG changes, adverse reactions and cognitive function in patients in the two groups were observed and compared. Results The ORR in group B was higher than that in group A（P〈0.05）. The changes in IEA and relative power of frequency bands α, β and δ after the treatment had no difference between the two groups（P〉0.05）. The relative power of θ in group B after the treatment was significantly higher than that before the treatment and that in group A after the treatment（ P〈0.05）. There were no severe adverse reactions. The VIQ in the two groups after the treatment was getting higher（P〈0.05）, but PIQ and FIQ had no significant difference（P〉0.05）. Conclusion Oxcarbazepine has better effect for adult partial epilepsy, but has greater impacts on EEG background activities than levetiracetam. The therapeutic schedule should be developed in accordance with specific conditions.