肺炎支原体肺炎患儿血清CRP、cTnT指标检测结果分析

Analysis of detection results of serum C-reactive protein and troponin in children with mycoplasma pneumonia

目的分析肺炎支原体肺炎(MPP)患儿血清C-反应蛋白(CRP)和肌钙蛋白(cTnT)的检测结果。方法选择我院收治的MPP患儿160例,另选择同期在我院进行体检的健康幼儿160例作为对照。对照组于体检日分别检测外周血免疫球蛋白IgM、IgA、IgG和IgE水平、CD4+和CD8+T细胞水平、CRP和cTnT水平;MPP组在确诊日,检测上述指标,并分别在治疗前、治疗后2 d和7 d检测CRP和cTnT水平。结果治疗前,MMP组IgG、IgM及IgE水平均显著高于对照组(P<0.05),CD4+细胞占比及CD4+/CD8+均显著低于对照组,而CD8+细胞占比明显高于对照组(P<0.01)。治疗前,MPP组血清CRP和cTnT水平显著高于对照组(P<0.01);治疗后,MPP组血清CRP和cTnT水平迅速下降,治疗7 d后基本恢复至对照组水平(P>0.05)。结论 MPP患儿体内细胞免疫和体液免疫功能均显著降低。血清CRP和cTnT可作为MMP诊断以及病情评估的参考指标。

Objective To study the detection results of serum C-reactive protein（CRP） and troponin（cTnT） in children with mycoplasma pneumonia（MPP）. Methods 160 children with MPP were enrolled and 160 normal children received health examination in our hospital were selected as the control group. The levels of serum immunoglobulin（IgM, IgA, IgG and IgE）, CD4＋, CD8＋T, CRP and cTnT of both groups were detected before and after treatment. Results Before the treatment, the level of IgG, IgM, IgE of MPP group were higher than those of the control group（P〈0.05）. The levels of CD4＋, CD4＋/CD8＋of the MPP group were lower than those of the control group（P〈0.05）, but the level of CD8＋of the MPP group was higher than that of the control group（P〈0.01）. Before the treatment, the levels of CRP and cTnT of the MPP group were higher than those of the control group（ P〈0.01）. After the treatment,the levels of CRP and cTnT of the MPP group decreased rapidly and restored to the levels of the control groups in the seven days（ P〈0.05）. Conclusion The activities of cellular and humoral immunity of MPP children decrease significantly and the levels of serum CRP and cTnT can be used as the indexes to diagnose and evaluate the conditions of MPP in children.