38例胃肠道间质瘤临床诊治及预后影响因素

Clinical treatment and prognosis of 38 cases of gastrointestinal stromal tumor

目的探讨胃肠道间质瘤(GIST)的临床治疗及其预后影响因素。方法回顾分析2008年1月-2015年12月38例经手术治疗GIST患者的临床病例资料,比较相关因素对患者预后的影响。结果38例患者中男27例,女11例,中位年龄56.5岁,肿瘤位于胃24例,小肠9例,食管1例,结直肠4例,患者随访时间1-60个月,随访期间5例(13.3%)发生术后复发和(或)转移。Logistic回归分析显示,肿瘤部位、大小、肿瘤是否破裂和核分裂像与GIST患者预后有关。COX回归模型显示,肿瘤部位和核分裂像是影响GIST患者预后的独立因素(P<0.05)。结论 GIST缺乏特异性临床表现,肿瘤部位和核分裂像是影响GIST患者预后的独立危险因素。

Objective To study the clinical characteristics, treatment and prognostic factors of gastrointestinal stromal tumor. Methods By retrospective analysis from January 2008 to December 2015 Hangshan Municipal′s people Hospital 38 cases of surgical treatment of patient with GIST clinical data to compare related factors on the prognosis of patients. Results Among 38 cases, 27 were men, 11 were women, and the median age was 56.5 years of age. 24 cases were located in the stomach, 9 cases in small intestine 4 in colorectal 4, 1 in esophagus ease. Patients with follow-up of 1-60 mouths, there were 5 cases （13.3%） occurred during follow-up postoperative recurrence and （or） transfer 1 cases died. Logistic regression analysis showed that tumor site size tumor rupture and fission as related to the prognosis of patient with GIST.COX regression model shows that the tumor site and fission like the indcpendent risk factors affecting the prognosis of patient with GIST （P〈0.05）. Conclusion Tumor site and fission like independent risk factors affecting the prognosis of patients with GIST.