2015年某院感染鲍氏不动杆菌的分布特点及耐药率分析

Distribution characteristics and drug resistance of Acinetobacter baumannii in nosocomial infections in 2015

目的了解某院感染鲍氏不动杆菌的分布特点以及耐药性,为临床抗感染用药提供依据。方法选取某院2015年1-12月医院感染鲍氏不动杆菌,采用K-B纸片扩散法进行药敏试验,并分析其耐药性。结果306株鲍氏不动杆菌主要分布在外科重症监护病房、内科重症监护病房和神经外科,分别占27.1%、23.5%和13.1%;标本来源以痰液为主,占77.5%;医院感染部位以下呼吸道感染、呼吸机相关性肺炎、菌血症为主,分别占40.5%、38.6%和6.9%;鲍氏不动杆菌对米诺环素有较高的敏感性,对头孢哌酮/舒巴坦、亚胺培南、美罗培南的耐药率分别为33.1%、65.9%和80.8%。结论鲍氏不动杆菌感染以呼吸道感染为主,临床科室应根据药敏结果合理选用抗菌药物,以降低患者感染率。

Objective To understand distribution characteristics and drug resistance of Acinetobacter baumannii in nosocomial infection, to provide the basis for clinical use of drugs. Methods Select the Acinetobacter baumannii of nosocomial infection from January 2015 to December 2015, K-B paper diffusion method is adopted to test the drug sensitivity and analyze its resistance. Results 306 strains of Acinetobacter baumannii are mainly distributed in Surgical intensive care unit （27.1%）, Medical intensive care units （23.5%）, Neurosurgery （13.1%）;Sputum was a major source of specimen （77.5%）;The common sites of nosocomial infection were respiratory tract , ventilator associated pneumonia and bacteremia , accounted for 40.5%, 38.6%and 38.6%respectively; Minocyline has higher sensitivity. The resistant rate of Cefoperazone/sulbactam , Imipenem, Meropenem was 33.1%, 65.9% and 80.8% respectively. Conclusion The main infection site of Acinetobacter baumannii was respiratory tract. We should be more reasonable to choose antimicrobial agents according to the result of drug sensitivity. In this way, In this way ,we can reduce the incidence of hospital infection.