摘要
目的探讨葛根素抑制大鼠离体结肠平滑肌收缩活动的作用机制。方法制备大鼠离体结肠平滑肌标本,用PowerLab数据采集分析系统记录结肠平滑肌收缩活动的变化。结果葛根素对大鼠离体结肠平滑肌的收缩活动具有明显抑制作用(P<0.05);阿托品、尼莫地平、普萘洛尔和格列本脲对结肠平滑肌收缩活动无明显作用(P>0.05),但可部分阻断葛根素对平滑肌收缩的抑制作用(P<0.05)。结论葛根素对大鼠离体结肠平滑肌收缩活动的抑制作用可能由β受体、M受体、K+通道和Ca2+通道所介导。
Objective To explore the mechanisms of supressing the contractile activity of isolated colon smooth muscle of rats with Puerarin .Methods Powerlab signal processing instrument was used to observe the activity of isolated colon smooth mus‐cle of rats .Results Puerarin significantly exerted depressant effect on the contractile activity of the colon smooth muscle of rats .Atropine ,nimodipine ,propranolol and glibenclamide partially blocked the depressant action of puerarin .Conclusion Pu‐erarin inhibited the motility of the colon smooth muscle of rats ,which was partially mediated via adrenergic βreceptor ,cholin‐ergic M receptor ,potassium channel and calcium channel .
出处
《滨州医学院学报》
2016年第5期324-326,共3页
Journal of Binzhou Medical University
基金
山东省高等学校科技计划(J13LL71)
关键词
葛根素
离体结肠平滑肌
Β受体
M受体
K+通道
CA2+通道
puerarin
isolated colon smooth muscle
adrenergicβreceptor
cholinergic M receptor
potassium channel
calci-um channel
