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保护心血管的新型脂肪因子——网膜素 被引量:1

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摘要 脂肪因子(adipokines)是由脂肪组织分泌的细胞因子,广泛参与调节能量、脂代谢及血管内皮功能平衡。网膜素(omentin)是由网膜脂肪组织分泌的一种脂肪因子,参与调控机体炎症反应、动脉粥样硬化形成及心血管疾病的发生、发展。网膜素可以通过多种途径抑制炎症,保护心脏功能;还可通过多途径增强胰岛素敏感性来改善心血管功能;此外,网膜素还可通过调节内皮功能,舒张血管,促血管再生,防止动脉粥样硬化。因此,网膜素可能成为心血管疾病诊断的潜在的分子标志性或药物作用靶点。本文就网膜素在心血管方面的研究进展进行综述。
作者 张华 赵德强
出处 《岭南心血管病杂志》 2016年第5期619-622,共4页 South China Journal of Cardiovascular Diseases
基金 国家中医药管理局重点专科老年科建设项目(项目编号:A-145) 上海市医学重点专科建设计划项目-心血管内科(项目编号:ZK2015A17)
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参考文献31

  • 1KRAL KRALISCH S, KLEIN J, BLUHER M, et al. Therapeutic perspectives of adipocytokines [ J ]. Expert Opin Pharmacother, 2005, 6(6) : 863-872.
  • 2YANG R Z, LEE M J, HU H, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action [J ]. Am J Physiol Endocrinol Metab, 2006, 290(6): 1253-1261.
  • 3LEE J K, SCHNEE J, PANG M, et al. Human homologs of the Xenopus oocyte cortical granule lectin XL35 [J]. Glycobiology, 2001, 11(1): 65-73.
  • 4TAN B K, ADYA R, RANDEVA H S. Omentin: a novel link between inflammation, diabesity, and cardiovascular disease [ J ]. Trends Cardiovasc Med, 2010, 20(5): 143-148.
  • 5YAMAWAKI H, KURAMOTO J, KAMESHIMA S, et al.Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells [J]. Biochem Biophys Res Commun, 2011, 408(2) : 339-343.
  • 6MARUYAMA S, SHIBATA R, KIKUCHI R, et al. Fat- derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism [ J ]. J Biol Chem, 2012, 287 ( 1 ) : 408-417.
  • 7ZHONG X, LI X, LIU F. Omentin inhibits TNF-a-induced expression of adhesion molecules in endothelial cells via ERK/ NF-jB pathway [J]. Biochem Biophys Res Commun, 2012, 425(2) : 401-406.
  • 8KAZAMA K, USUI T, OKADA M, et al. Omentin plays an anti-inflammatory role through inhibition of TNF-ct-induced superoxide production in vascular smooth muscle ceils [J]. Eur J Pharmacol, 2012, 686(1-3): 116-123.
  • 9XIANG K, WANG Y, ZHENG T, et al. Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21- q23 and chromosome lq21-q24[J]. Diabetes, 2004, 53 ( 1 ) : 228-234.
  • 10GOODPASTER B H, DELANY J P, OTYO A D, et al. Efects of diet and physical activity interventions on weight lOSS and cardiometabolic risk factors in severely obese adults:a randomized trial[J]. JAMA, 2010, 304(16): 1795-1802.

二级参考文献45

  • 1Xiu-Hua Wang,Ling-Zhi Dou,Can Gu,Xiao-Qing Wang.Plasma levels of omentin-1 and visfatin in senile patients with coronary heart disease and heart failure[J].Asian Pacific Journal of Tropical Medicine,2014,7(1):55-62. 被引量:38
  • 2魏红,杨桂彬,胡伏莲.幽门螺杆菌毒素及其与临床疾病相关性的研究进展[J].中华医学杂志,2005,85(37):2659-2662. 被引量:13
  • 3赵存新,张银华,李龙霞,董涛,周红美,金伟.国产雷贝拉唑治疗消化性溃疡疗效观察[J].国际消化病杂志,2006,26(4):287-288. 被引量:8
  • 4中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-419. 被引量:5228
  • 5Schaffler A,Neumeier M,Herfarth H,et al.Genomic structure of hum-an omentin,a new adipocytokine expressed in omental adipose tissue[J].Biochim Biophys Acta,2005,1732(1-3):96-102.
  • 6Yang RZ,Xu J,Pray J,et al.Identification of omentin as a novel depo-t-specific adipokine in human adipose tissue:possible role in modulat-ing insulin action[J].Am J Physiol Endocrinol Metab,2006,290(6):E1253-1261.
  • 7de Souza Batista CM,Yang RZ,Lee MJ,et al.Omentin Plasma Levels and Gene Expression are Decreased in Obesity[J].Diabetes,2007,56:1655-1661.
  • 8Tan BK,Adya R,Farhatullah S,et al.Omentin-1,a Novel Adipokine,is decreased in Overweight Insulin Resistant Women with the Polycys-tic Ovary Syndrome:ex vivo and in vivo Regulation of Omentin-1by Insulin and Glucose[J].Diabetes,2008,57:801-808.
  • 9Tan BK,Adya R,Farhatullah S,et al.Metformin Treatment May Incr-ease Omentin-1Levels in Women With Polycystic Ovary Syndrome[J].Diabetes,2010,59:3023-3031.
  • 10Wurm S,Neumeier M,Weigert J,et al.Plasma levels of leptin,oment-in,collagenous repeat-containing sequence of26-kDa protein(CORS-26)and adiponectin before and after oral glucose uptake in slim adults[J].Cardiovasc Diabetol,2007,20(6):7.

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