幽门螺杆菌抗生素耐药相关菌体因素的研究进展

Bacterial factors associated with Helicobacter pylori antibiotic resistance

幽门螺杆菌(Helicobacter pylori,H.pylori)感染是最广泛的慢性细菌感染,与许多疾病的发生发展密切相关.近年来,随着根除治疗的不断应用,H.pylori抗生素耐药率也不断增高,导致根除疗效不断下降.在众多导致耐药根除失败的原因中,H.pylori菌体自身的某些因素是最主要的原因.H.pylori可以通过产生灭活抗生素的灭活酶、改变药物作用的结合靶位、阻止氧化还原电位的电子传递、影响抗菌药物渗透屏障与主动外排机制、改变细菌自身代谢状态等途径耐药.明确H.pylori产生耐药的机制,有助于针对性的研发新药,从而有效地根除H.pylori.本文就目前报道与抗生素耐药有关的H.pylori菌体因素及其耐药相关分子机制的研究现状做一综述.

Helicobacter pylori（H. pylori） infection is the most widespread chronic bacterial infection and is closely associated with many diseases.In recent years, however, H. pylori is becoming increasingly difficult to eradicate due to the growing antibiotic resistance. Among the reasons for the failed eradication, some factors of H. pylori itself play a main role. H. pylori can resist antibiotics by producing inactivating enzymes, changing the drug targets,preventing oxidation-reduction electron transfer, decreasing membrane permeability and activating efflux pump, changing bacterial metabolic state and so on. Elucidating the mechanism of antibiotic resistance will be helpful in developing new targeted drugs to effectively eradicate H. pylori. Here, we review the bacteria factors associated with H. pylori antibiotic resistance.