观察和分析应用阿托伐他汀治疗急性冠状动脉综合征的临床疗效

Observation and Analysis of the Clinical Efficacy of Atorvastatin in the Treatment of Acute Coronary Syndrome

目的:分析阿托伐他汀治疗急性冠状动脉综合征(急性冠脉综合征)的临床疗效。方法:选择稳定性心绞痛、不稳定性心绞痛、非ST抬高性心肌梗死、ST抬高性心肌梗死患者各50例,依据随机分组方式将患者平均分为常规他汀治疗组(阿托伐他汀10mg/d)、大剂量他汀治疗组(阿托伐他汀10mg/d),分别统计两组30天、90天、6个月、12个月期间不良心脏(MACE)事件、肝肾功能、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)。结果:服药6个月和12个月大剂量他汀治疗组发生MACE事件几率低于常规他汀治疗组,差异有统计学意义。服药1个月和3个月MACE发生率差异不显著(P>0.05);大剂他汀治疗组治疗前后ALT未发生明显变化,常规他汀治疗组治疗后ALT水平显著治疗前及治疗后大剂他汀治疗组ALT水平,差异有统计学意义(P<0.05)。治疗前后两组患者的Scr未发生明显变化,且两组水平差异不显著(P>0.05);治疗后大剂他汀治疗组患者的HDL-C、TG、TC、LDL-C水平低于常规他汀治疗组,TC、TG、LDL-C差异有统计学意义,HDL-C差异无统计学意义。结论:大剂量的他汀减少急性冠脉综合征患者近、远期心血管不良事件而且安全性良好。

Objective： To analyze the clinical effect of atorvastatin in the treatment of acute coronary syndrome.Methods：Of stable angina pectoris,not stable angina,non ST elevation myocardial infarction,ST segment elevationmyocardial infarction patients,50 cases in each,according to randomized patients were divided into conventional statintreatment group （atorvastatin 10mg/D）, high dose atorvastatin treatment group （A Fa atorvastatin 40mg/D）, respectively,the statistics of the two groups of 30 days,during the period of 90 days,6 months and 12 months adverse cardiac events（MACE）, liver and kidney function,high density lipoprotein cholesterol （HDL-C） and triglyceride （TG）, serum totalcholesterol （TC）, low density lipoprotein cholesterol （LDL-C）. Results：There was a statistically significant differencein the incidence of MACE events between 6 months and 12 months of high-dose statin treatment group than that ofthe conventional statin therapy group.Incidence of medication 1 month and 3 months MACE rate difference was notsignificant （P〉0.05）; high dose statin therapy group before and after treatment, ALT did not change significantly, afterroutine treatment with a statin treatment group ALT levels significantly before treatment and after treatment of high dosestatin therapy group, the level of alt, the difference is statistically significant （P〈0.05）. Before and after treatment theSCR of the two groups of patients with no obvious change and the differences between the two groups was not significant（P〉0.05）; treatment after high dose statin therapy groups HDL-C, TG, TC, LDL-C levels lower than the conventionalstatin treatment group, TC, TG, LDL-C differences have statistical significance, HDL-C were no statistical significance.Conclusion：High dose of statins in patients with acute coronary syndrome patients with near and long-term adversecardiovascular adverse events and good safety.