N-乙酰半胱氨酸对慢性阻塞性肺疾病急性加重期患者氧化应激的影响

Effect of N-Acetyl Cysteine on Oxidative Stress in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:探究N-乙酰半胱氨酸对慢性阻塞性肺疾病急性加重期患者氧化应激的影响。方法:选取本研究确诊为肺功能为Ⅱ级慢性阻塞性肺疾病急性加重期的患者64例,按照治疗方式分成观察组与对照组,再选择同期进行健康检查的健康人40例为健康组。对照组采用常规的治疗方式,观察组在此基础上使用N-乙酰半胱氨酸治疗。对比三组的谷胱甘肽硫转移酶的活力、抑制羟自由基能力和抗超氧阴离子自由基能力。结果:治疗前,观察组与对照组的GSH-ST活力、抑制羟自由基能力和抗超氧阴离子自由基能力无明显差异,且比较:治疗前,观察组与对照组对比无明显差异,结果(P>0.05)为差异无统计学意义,GSH-ST活力明显高于健康组,抑制羟自由基能力和抗超氧阴离子自由基能力明显低于健康组,结果(P<0.05)有统计学意义。治疗后,对照组较治疗前没有明显变化,观察组明显高于治疗前和对照组,结果(P<0.05)有统计学意义。结论:慢性阻塞性肺疾病急性加重期的患者GSH-ST活力会升高,抑制羟自由基能力和抗氧阴离子自由基能力会降低,存在氧化/抗氧化失衡的情况,应用N-乙酰半胱氨酸能有效改善氧化/抗氧化情况。

Objective： To explore the effect of N- acetyl cysteine on oxidative stress in patients with acute exacerbationof chronic obstructive pulmonary disease.Methods：In our hospital diagnosed as lung function for 64 cases of patients withacute exacerbations Ⅱ level in patients with chronic obstructive pulmonary disease, according to treatment is dividedinto the observation group and the control group, and then select the same period to the hospital for health examination ofhealthy people in 40 cases of healthy group. The control group was treated with routine treatment, and the observation groupwas treated with N- acetyl cysteine. The activity of glutathione s transferase, inhibition of hydroxyl radical and superoxideanion free radical were compared between the three groups.Results：Before treatment, there was no significant difference inthe activity of GSH-ST, inhibition of hydroxyl radical and superoxide anion free radical in the observation group and controlgroup.Before treatment, the observation group and the compared to that of control group had no significant difference,results （P〉0.05） as there was no statistically significant difference, gsh-st activity was significantly higher than that ofhealthy group, inhibition ability of hydroxyl free radicals and anti superoxide anion free radical ability was significantlylower than that in the healthy group, the results （P〈0.05） are statistically significant. After treatment, there was nosignificant change in the control group compared with before treatment, the observation group was significantly higherthan that before treatment and the control group, the results （P〈0.05） had statistical significance. Conclusion：Chronicobstructive pulmonary disease acute exacerbation patients gsh-st activity increased, inhibition ability of hydroxyl freeradicals and anti oxygen anion free radical ability will reduce, oxidant / antioxidant imbalance, using N-acetyl cysteine caneffectively improve the oxidant / antioxidant status.