微生态调节剂对急性感染性腹泻患者血清炎性因子、肠黏膜屏障功能、肠道菌群的影响研究

Influence of microecological modulators on serum inflammatory factors,intestinal mucosal barrier function,and intestinal flora of patients with acute infectious diarrhea

目的探讨微生态调节剂对急性感染性腹泻患者血清炎性因子、肠黏膜屏障功能、肠道菌群的影响研究,为临床治疗提供参考。方法选取2015年6月-2016年3月在医院诊治的急性感染性腹泻患者80例,随机分为微生态组与对照组,每组40例,对照组常规治疗,微生态组加双歧杆菌三联活菌散口服,观察治疗前、治疗3d时血清炎性因子及肠黏膜屏障功能及肠道菌群变化。结果微生态组腹痛及腹泻消失时间短于对照组(P<0.05),脱水消失时间两组比较差异无统计学意义;两组治疗前IL-6、TNF-α、DAO、D-乳酸、L/M、双歧杆菌、乳酸菌、肠球菌及肠杆菌比较差异无统计学意义,治疗后IL-6、TNF-α、DAO、D-乳酸、L/M、肠杆菌均较治疗前下降,双歧杆菌、乳酸菌较治疗前升高,比较差异有统计学意义(P<0.05)。结论急性感染性腹泻患者给予微生态调节剂治疗有助于缩短腹痛及腹泻改善时间,减轻炎性反应,保护胃肠道黏膜屏障功能,促进肠道菌群失调的恢复。

OBJECTIVE To explore the influence of microecological modulators on serum inflammatory factors, in- testinal mucosal barrier function, and intestinal flora of patients with acute infectious diarrhea so as to provide guidance for clinical treatment. METHODS A total of 80 patients with acute infectious diarrhea who were treated in hospitals from Jun 2015 to Mar 2013 were enrolled in the study and randomly divided into the microecological group and the control group, with 40 cases in each. The control group was given conventional therapy, and the microecological group was treated with additional oral administration of bifidobacterium triple viable. The serum in- flammatory factors, intestinal flora barrier function, and intestinal flora were observed before the treatment and after the treatment for 3 days. RESULTS The time of disappearance of abdominal pain and diarrhea of the rnicroeco- logical group was shorter than that of the control group （P〈0.05）; there was no significant difference in the time of disappearance of dehydration. There was no significant difference in the level of IL-6, TNF-α, DAO, D-lactic acid, L/M, bifidobacterium, Lactobacillus, Enterococcus, or Enterobacteriaceae between the two groups of pa- tients before the treatment. The levels of IL-6, TNF-α, DAO, D-lactic acid, L/M, and Enterobacteriaceae de- clined after the treatment, while the levels of biPidobacterium and Lactobacillus were elevated after the treatment, and there was significant difference （P〈0.05）. CONCLUSION The use of microecological modulators for treat- ment of the patients with acute infectious diarrhea may shorten the time of improvement of abdominal pain and diarrhea, alleviate the inflammatory reactions, protect the gastrointestinal mucosal barrier function, and promote the recovery of intestinal flora imbalance.