皮肌炎血清CXCL10水平与疾病活动度的相关性

The levels of serum CXCLIO in Chinese patients with dermatomyositis are associated with disease activity

目的检测DM患者血清CXCLl0水平并阐明其临床意义。方法ELISA检测61例DM患者、32名健康人血清CXCL10水平；利用国际肌炎组织制定的炎性肌病评价工具（MDAAT）评估DM患者疾病活动度，并分析血清CXCL10水平与疾病活动度的相关性。组间比较用独立Mann-Whitney U检验，相关牲分析采用Spearman秩检验。结果DM患者血清CXCL10水平[1002．65（446．80，1679．42）pg／ml]显著高于健康人[85．85（65．88，111．05）pg／ml；Z=-6．886，P=0．000]，合并肺间质病变（ILD）的DM患者血清CXCL10水平[1029．40（452．25，2102．10）pg／ml]高于未合并ILD者[464．25（161．65，1048．63）pg／ml；Z=-2．975，P=0．003]。横断面研究显示血清CXCLIO水平与DM患者的MYOACT-总活动度评分（r=614，P=0．000）、MYOACT-肌肉活动度评分（r=0．45，P=0．000）、MYOACT-皮肤黏膜活动度评分（r=0．439，P=0．000）、MYOACT-肺脏活动度评分（r=0．373，P=0．004）呈正相关。结论DM患者血清CXCL10水平显著升高，并且与疾病活动度显著相关。CXCL10可能参与DM发病机制，检测其血清浓度对疾病的活动情况及治疗预后具有一定临床提示意义。

Objective To investigate serum levels of CXCL10 in Chinese patients with dermatomyosiris （DM）, and illuminate its clinical significance. Methods Serum CXCL10 levels of 61 DM patients and 32 matched healthy controls were measured by enzyme linked immunosorbent assay （ELISA）. The score of disease activity was measured by the same doctor under the direction of MDAAT. And its correlation with serum levels of CXCL10 was analyzed. The results of two groups were compared using unpaired Mann-Whitney U test and the relevance was analyzed using Spearman correlation analysis. Results Serum levels of CXCL10 in DM patients were significantly higher than healthy controls [1 002.65 （446.80,1679.42） pg/ml vs 85.85 （65.88, 111.05） pg/ml; Z=-6.886, P=0.000]. Patients with ILD had higher serum CXCL10 levels than the patients without ILD （Z=-2.975, P=0.003）. A cross-sectional assessment revealed that serum CXCL10 levels were positively correlated with global disease activity （r=0.614, P=0.000）, muscle activity （r=0.45, P=0.000）, skin activity （r=0.439, P=0.000）, and lung activity （r=0.373, P=0.004）. Conclusion Serum CXCL10 levels are increased in DM and positively correlate with disease activity. The levels of serum CXCLI0 can reflect the disease activity and therapeutic efficacy of DM.