原发性肝癌患者血浆溶血磷脂酸的临床意义

Significance of Plasma Lysophosphatidic Acid Detection in patients with Primary Liver Cancer

目的:检测原发性肝癌患者血浆溶血磷脂酸(lysphosphaticlic acid,LPA)的水平,评价LPA在原发性肝癌诊治中的临床意义。方法:采用生物化学方法检测原发性肝癌患者43例,肝脏良性疾病患者10例及健康志愿者10名的血浆LPA水平,同时测定血清AFP的水平。结果:原发性肝癌患者血浆LPA水平(3.94±0.60)μmol/L明显高于肝脏良性疾病患者(2.68±0.36)μmol/L和健康对照组(2.42±0.35)μmol/L(P<0.05),血浆LPA水平的升高与原发性肝癌浸润和门静脉癌栓等相关。结论:血浆LPA检测为原发性肝癌诊断和预后判断增加了一项潜在的评价指标。

Objective： To observe the levels of plasma lysophosphatidic acid （ LPA ） in patients with primary liver cancer, and to evaluate its clinical potential of diagnosis.Method： Plasma LPA and serum AFP levels were measured in 43 patients with primary liver cancer, 10 patients with benign primary liver cancer tumor, and 10 patients healthy donors.Re.stilt： Plasma LPA concentration in primary liver eancerpatients （ 3.94 ±0.60 ） μmol/L was significantly higher than patients with benign lesions of （ 2.68± 0.36 ） μmol/L and control group of （ 2.42 ± 0.35 ） μmol/L （ P〈0.05 ） .Higher plasma LPA level showed a significant correlation with invasion andportal vein tumor thrombus （ PVTT ） of primary liver cancer.Conclusion： Plasma LPA level may be a potential indicator of the diagnosis and prognosis of primary liver cancer.