曲普瑞林治疗对子宫内膜异位症不孕腹腔镜术患者疗效及血清性激素的影响

Curative Effect and Serum Sex Hormones Influence of Triptorelin Treatment for Endometriosis of Infertility Patients with Laparoscopic Surgery

目的:探讨曲普瑞林治疗对子宫内膜异位症不孕腹腔镜术患者疗效及血清性激素的影响。方法:选取2012年6月-2015年1月期间本院确诊治疗的子宫内膜异位症不孕患者124例,依据随机分配原则分为联合组和三酮组,每组62例。两组患者均给予常规腹腔镜下剥除术治疗,术后三酮组患者在此基础上给予2.5 mg孕三烯酮口服治疗,联合组患者在此基础上给予3.75 mg曲普瑞林肌注治疗。采用酶联免疫吸附法(ELISA)检测血清雌二醇(E2)、卵泡刺激素(FSH)和黄体生成素(LH)水平,随访1年,统计分析所有患者临床疗效,治疗前后血清E2、FSH和LH水平及不良反应发生情况。结果:联合组患者治疗总有效率和受孕率明显高于三酮组,两组比较差异均有统计学意义(P<0.05)。治疗后,联合组患者E2、FSH和LH水平明显低于三酮组,两组比较差异均有统计学意义(P<0.05)。联合组和三酮组不良反应发生率分别为6.45%、9.68%,前者低于后者,但两组比较差异无统计学意义(P>0.05)。结论:曲普瑞林治疗可有效改善子宫内膜异位症不孕腹腔镜术患者血清E2、FSH和LH水平,提高患者的临床疗效,且具有良好的安全性,值得临床进一步推广。

Objective： To discuss the curative effect and serum sex hormones influence of Triptorelin treatment for endometriosis of infertility patients with laparoscopic surgery.Method： 124 patients with endometriosis infertile were selected from June 2012 to January 2015 in our hospital.According to the random distribution, all patients were divided into join group and three ketone group, 62 cases in each group, two groups of patients were given conventional treatment of laparoscopic removal, then three ketone group was given 2.5 mg pregnant three ）：etene oral treatment, join group was given 3.75 mg Triptorelin injection treatment, enzyme-linked immunosorbent （ ELISA ） was used to detect serum estradiol （ E2 ）, follicle-stimulating hormone （ FSH ） and luteinizing hormone （ LH ） levels.Followed up for 1 year, the clinical curative effect, before and after treatment serum E2, FSH and LH levels and adverse reactions occur of two groups were analysed.Result： Join group efficient and conception rate were obviously higher than the three ketone group, there were significant differences （ P〈0.05 ）. After treatment, the levels of E2, FSH and LH of join group were lower than the three ketone group, there were significant differences （ P〈0.05 ） .Join group and three ketone group incidence of adverse reactions were 6.45% and 6.45% respectively, the former was lower than the latter, but there was no significant difference （ P〉0.05 ） . Conclusion： Triptorelin treatment can effectively improve the endometriosis infertile laparoscopic surgery patients serum E2, FSH and LH levels, improve the patients＇ clinical curative＇effect, it has good security, it is worthy of further clinical promotion.