阿奇霉素联合噻托溴铵粉吸剂治疗慢性阻塞性肺疾病患者临床疗效观察

Clinical Efficacy of Azithromycin Combination with iotropium Bromide Powder Inhalation on Patients with Chronic Obstructive Pulmonary Disease

目的 :探讨阿奇霉素联合噻托溴铵粉吸剂治疗慢性阻塞性肺疾病患者的临床疗效。方法 :将我院收治的120例稳定期慢性阻塞性肺疾患者随机分为观察组和对照组,每组60例,对照组采用噻托溴铵单药治疗,观察组采用阿奇霉素联合噻托溴铵组治疗。比较两组治疗后的临床疗效及各项肺功能指标变化情况。结果 :两组患者治疗前6min步行距离、各项肺功能指标无明显差异,差异无统计学意义(P>0.05)。两组治疗后6min步行距离、各项肺功能指标(FVC、FEV1、FEV1/FVC)相较于治疗前均有显著改善,差异有统计学意义(P<0.05)。治疗后观察组6min步行距离、各项肺功能指标均明显优于对照组,差异有统计学意义(P<0.05)。结论:阿奇霉素联合噻托溴铵粉吸剂治疗慢性阻塞性肺疾病的临床疗效良好,值得临床推广使用。

Objective： To investigate the clinical efficacy of azithromycin combined with tiotropium bromide powder inhalation on patients with chronic obstructive pulmonary disease （COPD）.Methods： In total, 120 patients with chronic obstructive pulmonary disease （COPD） were admitted and tread in our hospital. They were randomly divided into test group and control group with 60 patients in each group. Patients in control group were treated with simplex tiotropium bromide, while patients in test group were treated with azithromycin combined with tiotropium bromide. After treatment, both groups were compared in clinical efficacy, and the changes of pulmonary function.Results： Before treatment, there were no significant difference in the 6-minute walking distance, and pulmonary function in both groups （P 〉 0.05）. However, after treatment, there were significant differences in the 6-minute walking distance and pulmonary function （FVC, FEV1, FEV1/FVC）, whose of test group had significantly better than those in control group （P〈0.05）. Conclusions： Azithromycin combination with Tiotropium Bromide Powder Inhalation has good clinical efficacy for patients with chronic obstructive pulmonary disease （COPD）, is worthy of clinical application.