急性脑卒中患者合并应激性溃疡相关危险因素分析

Analysis of Risk Factors for Acute Cerebral Stroke Patients Complicated with Stress Ulcer

目的：回顾性分析急性脑卒中患者合并应激性溃疡（SU）危险因素,为急性脑卒中患者合并应激性溃疡的预防治疗提供理论依据。方法：收集2 026例急性脑卒中患者的病例资料,并分为SU组及非SU组,采用单因素和多因素Logistic回归分析SU的相关危险因素。结果：急性脑卒中患者中SU的发生率为5.48%,合并SU患者死亡率（9.01%）远高于非SU患者（1.93%）。单因素分析表明,女性、年龄≥60岁、卒中类型为脑出血、卒中史、GCS评分3-8分、高血压史、糖尿病史、预防性抗凝或抗血小板治疗90d以上、禁食的急性脑卒中患者并发SU的发病率更高（P〈0.05）。结论：SU增加患者死亡率;女性、年龄≥60岁、高血压病史、预防性抗凝或抗血小板治疗90d以上、禁食为急性脑卒中患者合并SU的高危因素;抑酸治疗可降低脑卒中合并SU患者死亡率。

Objective：Toanalyze the risk factors of acute cerebral stroke（ACS）patient complicated with stress ulcer（SU）and provide reliable theory basis for prevention and therapy.Methods：The clinical data of 2 026 patients with ACS were collected,and the patients were divided into SU group and non SU group.Univariate analysis and multivariate Logistic regression analysis were used to investigate the risk factors for SU.Results：The incidence of SU in 2 026 patients with ACS was 5.48%.The mortality of SU group was 9.01%,which was much higher than 1.93% of non SU group.Single factor analysis shows that female,age≥60,cerebral hemorrhage,previous stroke history,Glasgow Coma Score（GCS）3-8,hypertension,diabetes,prophylactic anticoagulation or antiplatelet therapy more than 90 days,and fasting can increase the incidence of SU（P〈0.05）.Conclusion：SU can increase the mortality of patients with ACS.Female,age≥60,hypertension,prophylactic anticoagulation or antiplatelet therapy more than 90 days,and fasting were high risk factors for ACS patients complicated with SU.Acid suppression therapy can reduce the mortality of SU.