3.5%利多卡因眼用凝胶的研究进展

Research progression in 3.5% lidocaine ophthalmic gel

局部麻醉药在眼科的各类操作和手术中应用广泛,目前临床上使用的主要是表面麻醉药滴眼液。3.5%利多卡因眼用凝胶是眼科表面麻醉用新品,与表面麻醉药滴眼液相比,具有麻醉效果更好、有效麻醉作用时间更长、术中重复给药次数减少、角膜上皮毒性降低并能保护眼表等特性。本文介绍3.5%利多卡因眼用凝胶及其药代动力学、临床疗效和安全性方面的研究进展。

Topical anesthetics play an important role in both ophthalmic procedures and surgeries. Topical anesthetic eye drops are primarily used for ocular anesthesia in the current practice while 3.5% lidocaine ophthalmic gel is a novel ocular anesthesia. Compared with topical anesthesia eye drops, this ophthalmic gel has some advantages, including better anesthetic effect and longer duration, less times for intraoperative repeated administration, lower corneal epithelial toxicity and better ocular surface protection, The history of ophthalmic topical anesthetics is briefly reviewed and the characteristics, pharmacokinetics, clinical efficacy and safely of 3.5% lidocaine ophthalmic gel are also introduced in this article.