广西隆安县2006-2014年原发性肝癌回顾性调查研究

A retrospective study of hepatic carcinoma in Guangxi Long'an County: from 2006 to 2014

目的探讨广西隆安县原发性肝癌流行病学特征及危险因素。方法回顾性调查隆安县2006-2014年发病的原发性肝癌患者共2 170例,通过查阅纸质报告表、病案、肿瘤直报系统等方法收集其基本人口学资料、诊断与报告情况、乙肝病毒和丙肝病毒感染以及免疫接种情况,并对上述资料进行统计分析。结果病例以35岁以上中老年男性为主,平均年龄(57.22±14.61)岁,男女性别比为3.50∶1,壮族占绝大多数。2 170名研究对象中,457例(21.06%)患者乙型肝炎病毒表面抗原(hepatitis B surface antigen,HBs Ag)阳性,10例(0.46%)抗-丙肝病毒抗体(anti-hepatitis C virus Ig G,anti-HCV Ig G)阳性,3例HBs Ag和抗-HCV Ig G均为阳性。HBs Ag感染率为65.76%(457/695),丙肝病毒(hepatitis C virus,HCV)感染率为1.79%(10/558)。除24例研究对象乙肝疫苗接种史不详以外,其余均无乙肝疫苗接种史。2006-2014年粗发病率为60.50/10万,中国人口标化发病率为32.11/10万,世界人口标化发病率为43.60/10万。2012-2014年发病率出现逐年上升趋势。结论隆安县是肝癌高发区,且近年发病上升。乙肝病毒感染是隆安县肝癌发病主要危险因素之一。

Objective To investigate epidemiological characteristics and risk factors of primary hepatic carcinoma （ PHC ） in Guangxi Long＇ an County. Methods 2 170 PHC cases in Long＇ an County were retrospectively investigated by looking up to report forms on paper, medical record, and cancer direct report system. Information of basic demographic, diagnosis and report, infection of hepatitis B virus and hepatitis C virus, and status of immunization were collected and analyzed. Results Most of the study subjects were men over the age of 35. The mean age was 57.22± 14. 61 years. Male-fe- male sex ratio was 3.50 ： 1. Among the 2 170 study objects, 457 （21.06%） cases were HBsAg positive; 10 （0. 46% ） cases were anti - HCV IgG positive; 3 cases were both HBsAg and anti - HCV lgG positive. Most of the patients were Zhuang. Infection rates of HBV and HCV were 65.76% （457/695） and 1.79% （10/558） respectively. Except twenty four study subjects with unknown history of hepatitis B vaccination, there was no history of hepatitis B vaccination in other cases. Crude incidence rate during 2006 - 2014 was 60. 50 per 100 000. Population of China standardized morbidity was 32. 11 per 100 000. World population standardized morbidity was 43.60 per 100 000. Morbidity in 2012 -2014 demonstra- ted a trend of rising year by year. Conclusions Long＇ an County is a PHC high incidence region and the incidence rate in- creased considerably in recent years. HBV infection is one of the major PHC risk factors in Long＇ an County.