肿瘤坏死因子-α-1031T>C基因多态性与幽门螺杆菌易感性的Meta分析

Association between TNF-α-1031T>C polymorphisms and helicobacter pylori infection:a meta-analysis

目的探讨肿瘤坏死因子α（TNF-α）-1031T〉C基因多态性与幽门螺杆菌易感性的关系。方法计算机检索CNKI、维普数据库、万方数据库、Pubmed数据库、Cochrane图书馆及Embase数据库,查找TNF-α-1031T〉C基因多态性与幽门螺杆菌易感性相关的病例对照研究。采用STAT 12.0进行数据分析。应用OR及其95%CI表示其关联强度。结果共纳入10项病例对照研究,2 328例患者。Meta分析结果显示,与健康人群相比,累加遗传模型（TT vs CC,OR=0.61,95%CI=0.44~0.85,P=0.003）与显性遗传模型（TT＋CT vs CC,OR=0.61,95%CI=0.44~0.84,P=0.002）可能会降低Hp感染的风险,差异具有统计学意义（P〈0.05）。而等位基因模型（T vs C,OR=0.92,95%CI=0.82~1.02,P=0.106）和隐性遗传模型（TT vs CC＋CT,OR=0.96,95%CI=0.84~1.09,P=0.504）两组间差异无明显统计学意义（P〉0.05）。结论 TNF-α-1031T〉C基因累加遗传模型中TT基因频率和显性遗传模型中TT＋CT基因频率的增加是Hp感染的保护因素。该结论还需更多大样本多中心的研究论证。

Objective To investigate the association between TNF-α -1031 T 〉 C polymorphisms and helicobaeter pylori （H. pylori） infection. Methods Published literatures within CNKI, VIP Database, Wanfang Database, PubMed, Embase, and the Cochrane Library were searched. Data were analyzed with the Stata12. 0 software package using pooled odds ratios （ORs） with 95% confidence intervals （CI）. Results A total of ten studies involving 2 328 patients were included in this study. The results of meta-analysis showed that TNF-α -1031 T〉C polymorphisms was associated with decreasing H. plylori infection（TT vs CC, OR ： 0.61,95 % CI ： 0.44-0.85, P = 0. 003; TT＋CT vs CC, OR ：0.61,95% CI =0.44-0.84, P =0. 002）. However, there was no significant difference between allele model（T vs C, OR =0.92,95% CI ：0. 82-1.02, P =0. 106） and recessive model（TT vs CC＋CT, OR ： 0.96,95% CI ：0.84-1.09, P ：0. 504）. Conclusion TNF-α-1031 T〉C polymorphisms may be associated with a decreasing risk of H. pylori infection. Further studies with different ethnicities and larger sample size are required to validate the results.