早孕期规范化超声检查在胎儿畸形筛查中的应用价值

Application value of standardized ultrasonography during early pregnancy in fetal malformation screening

目的 探讨早孕期规范化超声检查对胎儿畸形的筛查价值.方法 随机选取2013年2月至2015年3月于本院行早孕期筛查孕妇1335例,均接受常规经腹规范化超声探查,对胎儿畸形发生情况及其NT值水平进行测量观察,并对其进行相关性分析.结果 本次研究中共计检出畸形胎儿14例,不同组别胎儿之间的NT值存在明显差异（F=259.779,P=0.000）.Pearson相关性分析显示,NT值同头臀径呈正相关（r=0.439,P=0.001）;Spearman相关性分析显示,随着孕周的增长,NT值逐渐增加（r=0.477,P=0.001）.结论 早孕期规范化超声筛查是一种有效的胎儿畸形诊断方法,有助于对各类畸形、染色体异常做出早期判断,并为产前诊断和侵人性检查提供可靠指导,有助于促进孕妇生活质量的改善和人口质量的提高,建议在临床进一步推广.

Objective To discuss the value of standardized ultrasonography during early pregnancy in screening fetal malformation.Methods 1335 pregnant women underwent early pregnancy screening in our hospital from February 2013 to March 2015 were randomly selected,who underwent routine standardized abdominal ultrasonography.Fetal malformation and NT value were observed and measured,and the correlation analysis was carried out.Results There were 14 cases of fetal malformation detected in the study.There was statistically significant difference in NT value among different groups （F=259.779,P=-0.000）.Pearson correlation analysis showed that NT value was positively correlated with crown-rump length （r=0.439,P=0.001）;Spearman correlation analysis shows that with the increase of gestational age,NT value gradually increased （r=0.477,P=0.001）.Conclusions Standardized ultrasonography during early pregnancy is an effective diagnostic method for fetal malformation,which is helpful to early judgment of all kinds of malformations,chromosomal abnormalities,provides reliable guidance for prenatal diagnosis and invasive tests,promotes the improvement of living quality of pregnant women and population quality,recommended further clinical promotion.