血清同型半胱氨酸和超敏C反应蛋白检测在原发性高血压患者中的价值分析

Analysis of the value of serum homocysteine and high sensitive C reactive protein detection in patients with essential hypertension

目的 分析血清同型半胱氨酸（Hcy）和超敏C反应蛋白（hs-CRP）检测在原发性高血压（essential hypertension,EH）患者中的价值.方法 选取本院2015年3月至2016年3月住院的EH患者68例作为观察组,并选取同期健康体检者68例作为对照组.分别采用循环酶法、增强免疫比浊法检测两组血清Hcy和hs-CRP水平,并比较观察组、对照组血清Hcy、hs-CRP水平,观察组高血压不同分级之间血清Hcy、hs-CRP水平及观察组男性、女性患者血清Hcy、hs-CRP水平.结果 观察组血清Hcy、hs-CRP水平均明显高于对照组（P＜0.01）.观察组患者随着高血压分级的增加,血清Hcy、hs-CRP水平也随之增高（P＜0.01）;1级与2级、3级,2级与3级间血清Hcy、hs-CRP水平比较差异有统计学意义（P＜0.01）.观察组男性患者血清Hcy、hs-CRP水平均显著高于女性患者（P＜0.01）.结论 Hcy、hs-CRP是EH的危险因素,在其发生、发展过程中起着重要作用.检测血清Hcy、hs-CRP对EH的诊断、预防及治疗有着重要价值.

Objective To analyze the value of serum homocysteine （Hcy） and high sensitive C reactive protein （hs-CRP） detection in patients with essential hypertension.Methods 68 hospitalized EH patients in our hospital from March 2015 to March 2016 were selected as observation group,and 68 healthy persons underwent physical examination were selected as control group.Serum Hcy and hs-CRP levels of two groups were detected with enzymatic cycling assay,enhanced immunoassay respectively.Then serum Hcy,hs-CRP levels of two groups,serum Hcy,hs-CRP levels of patients with different levels of hypertension in observation group,and serum Hcy,hs-CRP levels of male,female patients in observation group were compared.Results Serum levels of Hcy and hs-CRP in observation group were significantly higher than those in control group （P〈0.01）.In observation group,with the increase of the grade of hypertension,serum Hcy,hs-CRP levels also increased （P〈0.01）;there were statistically significant differences in serum Hcy,hs-CRP levels among patients with grade 1,2,and 3 hypertension （P〈0.01）.Serum levels of Hcy and hs-CRP of male patients were significantly higher than those of female patients in observation group （P〈0.01）.Conclusions hs-CRP and Hcy are risk factors of EH,which play important roles in the occurrence and development of EH.Detection of serum Hcy,hs-CRP is of great value in the diagnosis,prevention and treatment of EH.