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MicroRNA作为类风湿关节炎生物标志物的研究进展 被引量：1

MicroRNAs as potential biomarkers for rheumatoid arthritis
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摘要 MicroRNA作为一类转录后调控小分子，在类风湿关节炎的发病机制中扮演着重要角色，不仅有望成为治疗的新靶点，同时也为类风湿关节炎的诊断、治疗应答、病情监测提供了新的潜在生物标志物，近年来此方面研究取得可喜进展。本文就microRNA作为类风湿关节炎标志物的研究现况进行综述。 MicroRNAs play crucial roles in the pathogenesis of rheumatoid arthritis as negative reg- ulators of the expression of target genes by repressing translation or through direct cleavage of mRNAs. More evidences suggest microRNAs may be a novel class of biomarkers for the diagnosis and predicting response to treatment of rheumatoid arthritis, rather than potential therapeutic targets. This review aims to summarize the current advances of microRNAs as potential biomarkers for rheumatoid arthritis.
作者 王春雨 罗晓红 徐进
机构地区 兰州军区兰州总医院风湿免疫科
出处 《中国医师杂志》 CAS 2016年第10期1593-1596,共4页 Journal of Chinese Physician
关键词 微RNAs/代谢 关节炎 类风湿/代谢 综述 MicroRNAs/ME Arthritis, rheumatoid/ME Review
分类号 R593.22 [医药卫生—内科学]
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参考文献18

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二级参考文献12

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中国医师杂志
2016年 第10期

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