清热化痰法序贯治疗AECOPD疗效观察

Observation on the Therapeutic Effect of Removing Heat-phlegm Method in the Sequential Treatment of Chronic Obstructive Pulmonary Disease in Acute Exacerbation Period

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)给予痰热清注射液序贯治疗的临床疗效。方法将120例AECOPD患者按照随机数字表法分为观察组和对照组各60例,观察组在对照组基础上给予痰热清注射液序贯治疗,重点比较两组患者的症状改善情况、肺通气功能、降钙素原等相关临床指标,同时对比两组患者住院时间和住院费用。结果观察组的总有效率及临床症状改善情况优于对照组,差异有统计学意义(P<0.05);观察组FEV1/FVCF、EV1%预计值等指标治疗前后的差值均高于对照组,差异有统计学意义(P<0.05);观察组hs-CRP、PCT等指标治疗前后下降的幅度明显高于对照组,并且差异具有统计学意义(P<0.05);观察组住院时间及住院期间的费用较对照组均有明显降低。结论痰热清注射液序贯治疗AECOPD可促进临床症状缓解,改善通气功能,显著降低PCT及超敏CRP水平,临床疗效显著;同时可以缩短住院时间及减少住院费用,极大地减轻了患者的经济负担。

Objective To investigate the clinical effect of Tanreqing injection in the sequential treatment of chronic obstructive pulmonary diseases in acute exacerbation period （AECOPD）. Methods 120 cases of patients with AECOPD were divided into observation group of 60 cases and control group of 60 cases according to random number table method. The observation group received sequential treatment of Tanreqing injection on the basis of the control group. The patients＇ symptoms improvement, pulmonary ventilation function, calcitonin related clinical indicators as well as hospital time and hospitalization costs were compared. Results The total effective rate and the improvement on clinical symptoms of the observation group were better than that those of control group, and the difference was statistically significant （P 〈 0.05） . The FEV1% estimated value and FEV1/FVC lung ventilation function index difference of the observation group before and after treatment were higher than those of the control group, and the difference was statistically significant （ P 〈 0. 05 ）. The PCT and hs-CRP index decline of the observation group before and after treatment were obviously higher than those of control group, and the difference was statistically significant （P 〈 0. 05 ）. The hospitalization time and hospitalization costs of the observation group were significantly lower than those of the control group. Conclusion Tanreqing injection in the sequential treatment of AECOPD can promote the clinical symptoms, improve ventilation function, significantly reduce the PCT and allergic CRP level, and the clinical curative effect is distinct. At the same time, it can shorten the length of hospital stay, and reduce hospitalization costs and the economic burden of patients.