摘要
研究LSD1在乳腺癌、癌旁组织及乳腺腺病标本组织中的表达,及其与乳腺癌病理特征及预后的相关性。应用免疫组织化学检测60例乳腺癌浸润性癌患者的癌、癌旁组织及20例乳腺腺病石蜡包埋组织中LSD1的表达情况,及其与乳腺癌临床病理特征及预后的相关性。结果表明,LSD1在乳腺癌组织的表达高于癌旁组织及乳腺腺病组织(P<0.05),其表达与雌激素受体(ER)表达呈负相关(相关系数为-0.505,P<0.01)。LSD1高表达的乳腺癌患者的预后更差(P<0.05)。
The paper explored the clinical significance of LSD1 in breast cancer, adjacent tissues and breast adenosis tissues. 60 cases of breast cancer and adjacent tissues, along with 20 cases of breast adenosis tissues, were colleted and processed by immunohistochemistry. Differential expression of LSD1 were analyzed and correlated to clinicopathological features and prognosis. Expression of LSD1 were higher in breast cancer tissues than that in adjacent tissues and breast adenosis tissues（P〈 0.05）. It was negatively correlated to ER expression（the correlation coefficient =-0.505, P〈 0.01）. Poor prognosis were detected in patients with higher expression of LSD1（P〈0.05）.
出处
《莆田学院学报》
2016年第5期27-30,共4页
Journal of putian University
基金
莆田市科技局科研项目(2013S03(2))
