血清钙与急性脑出血患者血肿量的相关性研究

The correlation study of serum calcium and hematoma volume in patients with acute intracerebral hemorrhage

目的探讨急性脑出血患者的血清钙离子浓度与出血量的相关性。方法回顾性分析2012年10月至2014年8月北京市平谷区医院神经外科收治的185例急性脑出血患者的临床资料，包括患者的性别、年龄、入院时血压（收缩压和舒张压）、血糖、血小板计数、凝血功能、血肿部位、血肿量、血钙、血镁、血清谷丙转氨酶。探讨与急性脑出血患者血肿量相关的因素。相关性分析采用多重逐步线性回归验证以及方差分析方法检验。结果多重逐步线性回归分析表明，血钙和血糖均与急性脑出血患者的血肿量相关（均P〈0．05），而患者的年龄、人院时收缩压和舒张压、血清谷丙转氨酶、血镁、凝血酶原时间、纤维蛋白原含量、国际标准化（凝血酶原时间）比值、血小板计数与急性脑出血患者的血肿量无关（均P〉0．05）。急性脑出血患者的血肿量与血清钙离子水平呈负相关，与血糖水平呈正相关。结论血清钙离子水平可能能够反映脑出血血肿量的大小和病情危重程度。

Objective To investigate the correlativity between the serum calcium concentration and the hematoma volume in patients with acute intracerebral hemorrhage. Methods The clinical data of 185 patients with acute intracerebral hemorrhage admitted to the Department of Neurosurgery, Beijing Pinggu Hospital from October 2012 to August 2014 were analyzed retrospectively, including the patients＂ sex, age, blood pressure on admission （systolic and diastolic blood pressure）, blood glucose, platelet count, coagulative function, hematoma location, hematoma volume, serum calcium, serum magnesium, and glutamic-pyruvic transaminase. The factors associated with the amount of hematoma in patients with acute cerebral hemorrhage were investigated. Multiple stepwise linear regression and variance analysis were used for correlation analysis. Results Multiple stepwise linear regression analysis showed that both serum calcium and glucose were associated with the hematoma volume in patients with acute cerebral hemorrhage （ all P 〈 0.05 ）, and the patients＂ age, systolic and diastolic blood pressure on admission, serum glutamic- pyruvic transaminase, serum magnesium, prothrombin time, fibrinogen content, international standardization （prothrombin time） ratio, and platelet count were not associated with the hematoma volume in patients with acute cerebral hemorrhage （ all P 〉 0.05 ）. The hematoma volume in patients with acute cerebral hemorrhage was negatively correlated with the serum calcium level; it was positively correlated with the blood glucose level. Conclusions The serum calcium ion level may reflect the size of hematoma volume in cerebral hemorrhage and the severity of the disease.