复方丹参片与低分子肝素治疗对早发型重度子痫前期围产结局的影响

The effect of the perinatal outcome of Fufang Danshen tablets and low molecular weight heparin in the treatment of early onset severe preeclampsia

目的探讨复方丹参片与低分子肝素治疗对早发型重度子痫前期围产结局的影响。方法回顾分析2013年1月至2015年9月我院诊治的77例早发型重度子痫前期产妇的临床资料,根据给药的不同分为硫酸镁组(28例)、低分子肝素组(24例)及复方丹参组(25例),比较三组产妇的产后出血量、分娩情况及母体并发症发生情况。结果低分子肝素组和复方丹参组的产妇分娩孕周明显多于硫酸镁组,差异具有统计学意义(P<0.05);三组产妇并发胎盘早剥、术后出血、肾功能衰竭、肝功能损害、HELLP综合症、高血压脑病的发生率没有显著性差异(P>0.05)。结论复方丹参片与低分子肝素治疗早发型重度子痫前期产妇的疗效良好,可延长孕周,且不增加药物的不良反应。

Objective To discuss the effect of the perinatal outcome of Fufang Danshen tablets and low molecular weight heparin in the treatment of early onset severe preeclampsia. Methods The clinical data of 87 cases of patients with early onset severe preeclampsia in our hospital from January 2013 to September 2015 were retrospectively analyzed. They were divided into magnesium sulfate group （28 cases）, low molecular weight heparin group （24 cases） and Fufang Danshen group （25 cases） according to different drugs, and the amount of postpartum hemorrhage, delivery and maternal complications among three groups were compared. Results The gestational age of postpartum women in low molecular weight heparin group and the Fufang Danshen group were significantly more than that of magnesium sulfate group, the difference was statistically significant （P〈0.05）; The incidence rates of three groups had no significant difference in the concurrence of placental abruption, postpartum hemorrhage, renal failure, liver function damage, HEELP syndrome, and the incidence of hypertension.（P〉0.05）. Conclusion Fufang Danshen tablets and low molecular weight heparin has a good effect for patients with early onset severe preeclampsia. It can prolong the gestational age, but does not increase the drug adverse reaction.