肺炎克雷伯菌携带耐药基因可移动元件的研究进展

Progress of research on drug resistance genes carried by mobile genetic elements of Klebsiella pneumoniae

肺炎克雷伯菌(KPN)是医院内感染常见致病菌,且发病率和耐药率逐年增高;细菌可移动遗传元件(MGE)可携带耐药基因在同种或不同种菌株间转移、传播,加速KPN对临床抗菌药物的耐药及耐药菌的播散,给治疗带来极大困难。本文简述了KPN携带耐药基因MGE的相关研究进展,探讨KPN对β-内酰胺类、氨基糖苷类、喹诺酮类这三大临床抗菌药物的耐药机制。

OBJECTIVE K lebsiella pneumoniae is a common species of pathogen causing nosocomial infections ,the morbidity and drug resistance rate are increased year by year .The mobile genetic elements （MGE） that may carry resistance genes can transfer and spread among the same species or different species ,which may accelerate the drug resistance of the K .pneumoniae to the clinical antibiotics as well as the spread of drug‐resistant strains and bring great difficulties to the treatment .This paper briefly describes the progress of the related researches on MGE carrying with drug resistance genes in the K .Pneumoniae and explores the drug resistance mechanisms of the K .Pneumoniae to the three categories of clinical antibiotics ,includingβ‐lactams aminoglycosides and quinolones .