双歧杆菌三联活菌散辅助经鼻空肠营养对SAP患者实验室指标、并发症及经济性的影响

Effects of live combined bifidobacterium,lactobacillus and enterococcus via nasal jejunum nutrition on laboratory indexes,incidence rates of complications and economical efficiency in patients with severe acute pancreatitis

目的探讨双歧杆菌三联活菌散辅助经鼻空肠营养对重症急性胰腺炎(SAP)患者实验室指标、并发症发生率及经济性的影响。方法收治SAP患者50例,随机抽分为对照组与试验组,每组25例。分别采用经鼻空肠营养单用和在此基础上加用双歧杆菌三联活菌散辅助治疗;比较2组患者治疗前后实验室指标水平、胃肠功能评分,并发症发生率、住院时间及住院费用等。结果试验组患者治疗后实验室指标水平均显著优于对照组、治疗前,差异有统计学意义(P<0.05);试验组患者治疗后胃肠功能评分均显著低于对照组、治疗前,差异有统计学意义(P<0.05);试验组患者并发症发生率均显著低于对照组,差异有统计学意义(P<0.05);试验组患者住院时间和住院费用均显著优于对照组,差异有统计学意义(P<0.05)。结论双歧杆菌三联活菌散辅助经鼻空肠营养对SAP患者可有效改善实验室指标,促进胃肠功能恢复,降低并发症风险,并有助于减轻经济负担。

Objective To investigate the effects of live combined bifidobacterium, lactobacillus and enterococcus via nasal jejunum nutrition on laboratory indexes, incidence rates of complications and economical efficiency in patients with severe acute pancreatitis （SAP）.Methods Fifty patients with SAP who were admitted and treated in our hospital from January 2012 to December 2015 were randomly divided into control group （ n =25 ） and observation group （ n =25 ） .The patients in control group were treated only by nasal jejunum nutrition,however, the patients in observation group,on the basis of control group, were treated by live combined bifidobacterium, lactobacillus and enterococcus.The laboratory indexes, gastrointestinal function scores,incidence rates of complications, length of staying in hospital and hospitalization expenses were observed and compared between two groups.Results After treatment the laboratory indexes in observation group were suprior to those in control group and those before treatment （ P 〈0.05 ） .After treatment the gastrointestinal function scores in observation group were significantly lower than those in control group and those before treatment （ P 〈0.05） .The incidence rates of complications in observation group were significantly lower than those in control group （ P 〈0.05）.The length of staying in hospital and hospitalization expenses in observation group were superior to those in control group （ P 〈0.05）. Conclusion The live combined bifidobacterium, lactobacillus and enterococcus via nasal jejunum nutrition in treatment of SAP can effectively improve laboratory indexes, promote gastrointestinal function recovery, decrease incidence rates of complications,thus, which is helpful to reduce economic burden of patients.