双环吡咯酮类化合物的简便合成

Simple Synthesis of Bicyclic Pyrrole Ketone Compounds

建立了一锅法合成双环吡咯酮化合物的方法.该方法以杂环烯酮缩胺1为合成砌块,在1,4-二氧六环溶剂中,三乙胺作碱,与乙二醛在50℃下反应,一步法关环合成了双环吡咯酮类化合物3a^3i.该方法具有合成路线简洁、后处理简单、原料易得、产率高和操作简便等优点.

In this article, a one-pot protocol was established for the synthesis of bicyclic pyrrole ketone compounds. This method based on the building blocks of heterocyclic ketene aminals 1, which reacted with oxalaldehyde 2 in 1,4-dioxane at 50℃ and triethylamine as base. As a result, a series of bicyclic pyrrole ketone compounds 3a-3i have been synthesized. This reaction has some advantages such as simple synthetic route, readily available starting materials, high yields and simple work-up procedures.