连续性肾脏替代治疗与间歇性血液透析治疗重症急性肾衰的比较研究

Comparative Study of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in the Treatment of Acute Renal Failure

目的:研究分析连续性肾脏替代治疗与间歇性血液透析治疗重症急性肾衰的临床效果,为日后重症急性肾衰患者的临床治疗提供依据。方法:选取2013年4月-2015年10月笔者所在医院收治的42例重症急性肾衰患者,将其分为对照组(21例,间歇性血液透析治疗)和观察组(21例,连续性肾脏替代治疗)两组,观察比较两组患者的临床治疗效果。结果:治疗前两组患者尿素氮、血清肌酐及内生肌酐比较差异无统计学意义(P>0.05);治疗后两组患者的尿素氮、血清肌酐及内生肌酐均得到改善,观察组患者的尿素氮、血清肌酐及内生肌酐水平明显优于对照组,且观察组患者的1年生存率明显高于对照组,两组之间差异均有统计学意义(P<0.05)。结论:连续性肾脏替代治疗在重症急性肾衰患者的临床治疗中具有较高的应用价值,能够明显帮助患者改善症状,有效提升患者的生存率。

Objective：To study the clinical effect of continuous renal replacement therapy and intermittent hemodialysis in the treatment of acute renal failure,and to provide more evidence for clinical treatment of acute renal failure.Method：42 cases of severe acute renal failure were selected from April 2013 to October 2015 in the author＇s hospital,and divided into control group（21 cases of intermittent hemodialysis treatment） and observation group（21 cases ofcontinuous renal replacement therapy）.The therapeutic effect were compared between the two groups.Result：The blood urea nitrogen,serum creatinine and endogenous creatinine showed no significant difference between two groups before treatment（P〈0.05）.Urea nitrogen,serum creatinine and endogenous creatinineof two groups were improved after treatment,and urea nitrogen,serum creatinine and endogenous creatinine of observation group were significantly better than those of the control group.And the 1 years survival rate of patients in the observation group was significantly higher than that in control group, the difference between the two groups was statistically significant（P〈0.05）.Conclusion：Continuous renal replacement therapy in patients with acute renal failure has high clinical value,can significantly help patients to improve symptoms,and effectively improve the survival rate of patients.