多西他赛所致过敏性休克的治疗和护理

Treatment and nursing for a patient with anaphylactic shock induced by docetaxel

目的：探讨多西他赛所致过敏性休克的预防和治疗措施。方法：选取2013年3月至2016年3月北京朝阳区三环肿瘤医院内科收治360例使用多西他赛的病例资料,5例出现严重过敏反应。结果：5例患者在静脉输入多西他赛2~15 min内出现胸闷、窒息感、呼吸困难、低血压等过敏症状,给予抗过敏、吸氧、扩充血容量等治疗,均抢救成功。结论：用多西他赛前应严格进行预处理,严重过敏反应多数发生在用药15 min内,若准确及时治疗多不会造成严重后果。

Objective： To explore the prevention and treatment measures of anaphylactic shock caused by docetaxel. Methods： Among 360 patients who received docetaxel admitted into our department between March 2013 with March 2016, 5 cases had severe allergic reactions. Results： The main symptoms of allergy caused by docetaxel included chest tightness, dyspnea, hypotension in 2-15 min, and all were rescued successfully after anti-allergic therapy, oxygen uptake and expanding blood capacity. Conclusion： Strict preventive treatment should be taken before using docetaxel for reducing allergic reactions. The majority of severe allergic reaction happened in the first 15 min, which will not cause serious consequences if treated accurate and timely.