炔诺酮治疗无排卵性功能失调性子宫出血的临床效果分析

Clinical effect of norethindrone in treating anovulatory dysfunctional uterine bleeding

目的:探讨炔诺酮治疗无排卵性功能失调性子宫出血的临床效果分析。方法:通过分析2013年1月至2014年11月医院收治的146例无排卵性功能失调性子宫出血患者的临床资料,随机分为观察组和对照组,对照组患者给予决雌醇环丙孕酮片治疗,观察组患者给予炔诺酮进行治疗,治疗结束后观察两组患者临床疗效。结果:治疗结束后观察组临床有效率为98.63%,对照组临床有效率为79.45%,两组临床有效率组间差异有统计学意义(P<0.05)。两组患者治疗前经期天数、周期和血红蛋白水平组间差异无统计学意义(P>0.05),治疗后比较差异有统计学意义(P<0.05)。统计两组患者血性激素水平,结果显示治疗前血性激素水平指标组间差异无统计学意义(P>0.05),治疗后观察组E2、FSH、P和LH四项指标比较组间差异有统计学意义(P<0.05)。结论:使用炔诺酮治疗无排卵性功能失调性子宫出血患者可显著改善患者月经周期、血清性激素指标和血红蛋白指标,临床指导意义重大。

Objectives： To investigate the clinical effects of norethindrone in treating anovulatory dysfunc- tional uterine bleeding. Methods： The clinical data of 146 anovulatory dysfunctional uterine bleeding patients from January 2013 to November 2014 was analyzed and randomly divided into two groups. The control group was treated with estradiol cyproterone, while observation group was treated with norethindrone. The clinical efficacy of the two groups was observed after treatment. Results： After treatment, the clinical effective rate of observation group and control group was 98.63% and 79.45% respectively, with statistically significant difference （ P 〈 0. 05 ）. Before treatment, there was no significant difference in menstrual period and hemoglobin levels （ P 〉 0. 05 ）, while the difference after treatment was statistically significant （ P 〈 0. 05 ）. Difference in blood hormone levels before treat- ment was not statistically significant between the two groups （ P 〉 0.05 ）, while statistically significant difference was found between the two groups in E2, FSH, P and LH after treatment （P 〈 0. 05）. Conclusion： Norethindrone for treatment of dysfunctional uterine bleeding anovulatory patients can significantly improve patients＇ menstrual cy- cle, serum sex hormone index and hemoglobin index, with great clinical significance.