110例女性尖锐湿疣患者HPV亚型的感染特征研究

Infection features of HPV subtypes in 110 female patients with condyloma acuminata

目的:研究110例女性尖锐湿疣(CA)患者HPV亚型的感染特征,为临床治疗以及宣传教育提供数据支持。方法:选取我院2010年1月至2015年6月收治的110例尖锐湿疣女性患者,采用HPV分型试剂盒进行HPV分型检测,并通过调查问卷调查患者一般资料和焦虑抑郁状况,对收集到的数据进行分析处理。结果:110例CA患者全部为HPV阳性,检测为单一HPV感染的患者有69例(62.7%);多重HPV感染达41例(37.3%)。其中单一低危HPV感染以HPV11占比最高;单一高危HPV感染以HPV16最高。进一步的研究发现,年龄、收入水平与饮食习惯与不同危害类型的HPV感染分布有关。年龄越小,收入相对低以及喜食辛辣的患者更易得高危害型HPV感染。结论:不同亚型的HPV感染发生比率不同,其中与年龄、收入以及饮食习惯显著相关,在今后的治疗以及宣传教育上可以采取针对性的措施,值得临床上加以强调。

Objectives： To study the infection features of HPV subtypes in 110 female patients with condyloma acuminate（ CA）,to provide data support to the clinical treatment and public education. Methods： 100 female CA patients in our hospital from January 2010 to June 2015 were tested using HPV genotyping kit for HPV genotyping. Questionnaire survey was conducted to learn general information and anxiety and depression level of patients. Results： All the 110 CA patients were HPV positive,including 69 cases of only HPV infection（ 62. 7%）and 41 cases of multiple HPV infection（ 37. 3%）. For single low- risk HPV infection,HPV11 had the highest proportion,while for single high- risk HPV infection,the proportion of HPV16 being the highest. Further study found that age,income level and eating habits and different types of hazards were all related to the distribution of HPV infection. People at younger age,with relatively low incomes and preferring spicy food were more susceptible to HPV infection of high hazard. Conclusion： The incidence of different subtypes of HPV infection is different,which is significantly correlated with age,income and diet. Therefore,targeted measures should be taken in future treatment and public education.