糖尿病患者心理安全感与情绪状态、C肽关系

Relation of Sense of Security and Negative Emotion,C-Peptide in Diabetes Mellitus Patients

目的:探讨糖尿病人心理安全感与情绪状态、C肽的关系,为糖尿病的预防和改善生活质量提供科学依据。方法:采用随机取样法选取在2014年3月—2015年10月入我院就诊的2型糖尿病患者84人,并施测汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD),检测其外周血C肽水平。结果:糖尿病人中确定存在焦虑的为57人(67.86%),至少存在轻度或中度抑郁的为73人(86.90%)。糖尿病人的人际安全感与HAMA(r=-0.58,-0.64;P<0.01)、HAMD各因子呈显著负相关(r=-0.52^-0.25,P<0.05);除体重外,确定控制感与HAMA、HAMD其他各因子呈显著负相关(r=-0.68^-0.24,P<0.05或0.01)。C肽与心理安全感、焦虑、抑郁的相关显著(r=0.90,-0.61,-0.74;P<0.01)。焦虑、抑郁、心理安全感进入糖尿病人C肽水平的回归方程,对C肽有显著预测作用(t=-5.095,-2.417,9.848;P<0.05)。结论:糖尿病人心理安全感与焦虑、抑郁水平密切相关;外周血C肽水平与情绪状态存在一定的关联。

Objective：To explore the relationship of sense of security,negative emotion and C-Peptide,and provide solitary scientific evidence of diabetes prevention and improving of quality of life.Methods：By random sampling,84 diabetes patients of inpatient and outpatient in rehabilitation department of the aged were recruited to be assessed by Hamilton Anxiety Rating Scale（HAMA）and Hamilton Depression Rating Scale（HAMD）,and C-Peptide in peripheral blood was also tested.Results：67.86% of patients reported significant anxiety（cut score≥14）and 86.90% depressive symptoms had clinical significance（cut score≥20）.Interpersonal security was negatively correlated to all the subscales of HAMA（r=-0.58,-0.64;P〈0.01）and HAMD（r=-0.52--0.25,P〈0.05）;Certainty in control was negatively correlated to the two factors of HAMA and all factors of HAMD except the body weight（r=-0.68--0.24,P〈0.05）.Correlation coefficients of sense of security,anxiety and depression with C-Peptide were as the following：0.90,-0.61,-0.74;P〈0.01;Anxiety,depression and sense of security were selected into the regressive equation of C-Peptide level in peripheral blood and had significantly predictive effects on C-Peptide level（t=-5.095,-2.417,9.848;P〈0.05）.Conclusion：Diabetes patients＇ sense of security has close relationship with anxiety and depression,C-Peptide level in peripheral blood may associate with emotional state which indicated function ofβ-cell of insulin.