儿童期受虐与肠易激综合征关系的临床研究

A Clinical Study of Childhood Abuse on Irritable Bowel Syndrome

目的：探讨儿童期受虐在肠易激综合征（IBS）发生及患者精神心理状态、生活质量中所起的作用。方法：72例IBS患者（患者组）评定儿童期虐待问卷（CTQ）,评估儿童期受虐情况,并与92例正常健康人（对照组）进行对照。IBS患者同时还评定抑郁自评量表（SDS）、焦虑自评量表（SAS）、肠易激综合征患者生活质量表（IBSQOL）。结果：①患者组CTQ评分显著高于对照组,差异有统计学意义（t=3.590,P〈0.001）;患者组儿童期受虐发生率为44.4%,高于对照组的27.2%,差异有统计学意义（χ^2=5.313,P〈0.05）;②与无儿童期受虐的IBS患者（40例）比较,有儿童期受虐的IBS患者（32例）SAS评分显著较高,差异有统计学意义（t=2.099,P〈0.05）;③有儿童期受虐的IBS患者QOL评分显著高于无儿童期受虐的IBS患者,差异有统计学意义（t=-2.223,P〈0.05）。结论：儿童期受虐可能是IBS发生的社会心理学因素之一,并可能对IBS患者的心理状况、生活质量产生不良的影响。

Objective：To explore the clinical correlativity of childhood abuse and irritable bowel syndrome cause,psychological symptoms and quality of life.Methods：A clinical childhood abuse survey was conducted with childhood trauma questionnaire（CTQ）in 72 cases of patients with irritable bowel syndrome（case group）and 92 cases of health（control group）.All patients with irritable bowel syndrome were also assessed by self-rating depression scale（SDS）,self-rating anxiety scale（SAS）,and the irritable bowel syndrome quality of life questionnaire（IBS-QOL）.Results：Compared to controls,patients with irritable bowel syndrome had higher scores of CTQ（t=3.590,P〈0.001）,and higher prevalence of childhood abuse（27.2%vs 44.4%,χ^2=5.313,P〈0.05）.Irritable bowel syndrome patients with childhood abuse（n=32）showed significantly increased scores of SAS（t=2.099,P〈0.05）and decreased scores of IBS-QOL（t=-2.223,P〈0.05）than those without childhood abuse.Conclusion：Childhood abuse may be associated with the cause psychological symptoms,and quality of life in irritable bowel syndrome patients